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Abbey MSII Unit 1 pt 2 > Pharm cancer IV > Flashcards

Pharm cancer IV Flashcards

1
Q

imatinib class

A

tyrosine kinase inhibitor (CML)

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2
Q

imatinib mechanism

A

inhibits abl kinase by binding where ATP should go; also inhibits PDGFR and c-kit; metabolized by cytochrome P450

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3
Q

imatinib side effects

A

nausea, vomiting, fluid retention, muscle cramps, arthralgia

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4
Q

rituximab mechanism

A

CD20 B-cell antibody that can directly activate apoptosis, complement, or cell-mediated cytotoxicity (non-hodgkin’s lymphomas)

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5
Q

rituximab side effects

A

infusion reactions, tumor lysis syndrome, severe mucocutaneous reactions, progressive multifocal leukoencephalopathy

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6
Q

trastuzumab mechanism

A

HER2/neu receptor antibody mechanism

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7
Q

trastuzumab side effects

A

hypersensitivity reaction; ventricular dysfunction

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8
Q

ado-trastuzumab emtansine (kadcyla) class

A

antibody-drug conjugate

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9
Q

ado-trastuzumab emtansine (kadcyla) mechanism

A

conjugate undergoes receptor-dependent internalization and drug is released inside the cell

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10
Q

ado-trastuzumab emtansine (kadcyla) side effects

A

fatigue, nausea, musculoskeletal pain, thrombocytopenia, headache, hypokalemia, peripheral neuropathy, ventricular dysfunction, interstitial lung disease

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11
Q

nivolumab mechanism

A

antibody that prevent T cell from turning off by inhibiting programmed cell death protein 1

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12
Q

nivolumab side effects

A

rash, itching, couch, upper resp tract infections, edema, fatigue, SOB, musculoskeletal pain, decreased appetite, nausea, consitpation

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13
Q

vemurafenib class

A

serine/threonine kinase inhibitor

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14
Q

vemurafenib mechanism

A

inhibits oncogenic BRAF kinase`

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15
Q

vemurafenib side effects

A

arthralgia, fatigue, photosensitivity, nausea, alopecia, diarrhea, QT prolongation

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16
Q

dabrafenib class

A

serine/threonine kinase inhibitor

17
Q

dabrafenib mechanism

A

inhibits oncogenic BRAF kinase

18
Q

dabrafenib side effects

A

serious febrile drug reactions, uveitis and iritis, hyperglycemia, hyperkeratosis

19
Q

trametinib class

A

dual specificty kinase

20
Q

trametinib mechanism

A

inhibits MEK

21
Q

trametinib side effects

A

cardimyopathy, retinal disorders, interstitial lung disease, serious skin toxicities

Abbey MSII Unit 1 pt 2 (21 decks)

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