[PHARM] Drugs for Movement Disorders [Kruse] Flashcards
1
Q
A
B. Parkinson Disease
2
Q
A
C. Substantia nigra
3
Q
How can individuals with parkinsons disease be treated?
A
Agents that activate dopamine receptors
and/or
Block muscarinic receptors
4
Q
A
B. Carbidopa
5
Q
What is carbidopa?
A
DOPA decarboxylase inhibitor
It does NOT cross the blood-brain barrier
It overall increases the half life, plasma levels and levodopa available for entry into the brain —–> This REDUCES the daily requirements of levodopa
6
Q
A
D. Multiple episodes of immboility per day
7
Q
A
E. Tolcapone
8
Q
A
A. Hepatotoxicity
9
Q
A
C. On-off phenomenon
10
Q
A
B. Apomorphine
(Only injectable)
11
Q
A
B. Dopamine (D2)
Apomorphine is a DA agonist
12
Q
A
A. Amantadine
13
Q
A
B. To help correct further the dopamine-ACh imbalance that accounts for parkinsonian signs and symptoms
14
Q
A
C. Add benztropine
15
Q
A
