[PHARM] Dementia [Iszard] Flashcards
What are the major therapeutic uses of agents that stimulate AChRs (direct and Indirect)
Glaucoma/ Accomodative Esotropia
GI and Urinary Tract
NMJ (Myasethenia Gravis etc)
Atrial Arrhythmias
Alzheimers Dz
Patients with Progressive Dementia (Alzheimer type) have a deficiency of what?
Intact cholinergic neurons
What medications replaced Tacrine for patients with Dementia, and why?
Donepezil
Rivastigmine
Galantamine
Physotigmine
–> they have less severe AE
Does the use of AChE inhibitors prevent disease progression in dementia patients?
No, it only slows it.
(It increases the amount of ACh in the patient)
When treating a patient with Alzheimers is the pharmacological therapy indicated for the entire span of the illness?
No! It should be discontinued in patients who do not appear to be benefiting or who have significant SA
What are the first line drugs for Alzheimers?
Donepezil
Galantamine
Rivastigmine
Which of the Alzheimers drugs can be taken in Cap, Soln, or Patch form?
Rivastigmine
Which Alzheimers drug is taken as a once daily disintegrating sublingual tablet?
Donepezil
Which Alzheimers drug is taken as a ER QD Capsule?
Galantamine
When taking ACh Inhibitors what types of drugs, when taken together, can induce Bradycardia or alter AV Conduction?
Beta Blockers
Ca Channel Blockers
Lacosamide
Galantamine should not be used in which types of patients?
End Stage Kidney Dz
or
Severe Hepatic Impairment
Rivastigmine (patch form) requires what?
Dose Adjustment for Hepatic Impairment and Low Body Weight
Patients with Sick SInus Syndrome or Incomplete Heart Block are at a higher risk of fall/fractures/syncope due to what effects of ACh Inhibitors?
Enhanced Vagal tone
Donepezil (Aricept) is indicated for what?
Tx of Dementia of Alzheimers
(Mild, Moderate, and Severe AD)
Galantamine is indicated for what?
Tx of Mild/Moderate dementia (Alzheimers type)
