Pharm - Biologics and Targeted Therapy

Question 1

-mab

Answer 1

monoclonal Ab

Question 2

-omab

Answer 2

murine MoAb

Question 3

-ximab

Answer 3

chimeric MoAb

Question 4

-zumab

Answer 4

humanized MoAb

Question 5

-umab

Answer 5

(fully) human MoAb

Question 6

Rituximab

MOA
uses

Answer 6

anti-CD20 (NHL)
IgG

also: 
RA
solid organ transplant rejection prevention
vasculitis
pemphigus

Question 7

Rituximab

AE

Answer 7

immunosuppressive

• reactivation of hep B
• PML
• Infusion related rxns
• tumor lysis syndrome
• HAMA/HACA
• skin rxns, N/V

Question 8

cetuximab

MOA/uses

Answer 8

• binds to cell surface of EGFR

- uses: colerectal, H and N, lung

Question 9

cetuximab

AE

Answer 9

• infusion related rxn
• ACNEIFORM RASH
• asthenia
• N/V
• hepatotoxicity

Question 10

trastuzumab

MOA/use

Answer 10

(herceptin)

• anti-HER2
• unconjugated, IgG

Question 11

trastuzumab

AE

Answer 11

• infusion-related rxn
• generalized pain, asthenia, HA
• myelosuppression
• cardiotoxicity

Question 12

bevacizumab

MOA
uses

Answer 12

• anti-VEGF
• colorectal, lung, breast, renal, wet macular degeneration
• black box warning (impaired wound healing, GI perforation, hemorrhage)
• HTN
• thombotic events
• bleeding episodes

Question 13

TKIs for Bcr-Abl (CML)

AE

Answer 13

Imatinib

• edema, fluid retention
• cytopenias
• elevated LFTs
• cardiotoxicity

Question 14

TKIs for renal cell carcinoma

AE

Answer 14

sunitinib

• GI, liver
• skin

Question 15

“-imids”

Answer 15

• thalidomide
• lenalidomide
• pomalidomide

Question 16

“-imids”

MOA

Answer 16

antiangiogenesis 
-inhibit basic fibroblast gfac
-inhibit VEGF
immunomodulatoru
induce apoptosis

Question 17

“-imids”

AE

Answer 17

• neurotoxicity
• sensory sx
• sedation
• depression
• cardio (bradycardia. peripheral edema, thrombosis)
• TERATOGEN (***thalidomide)

Question 18

hypomethylating agents

MOA

Answer 18

(certain tumors have hypERmethylation –> silences tumor suppressors)

hypOmethylators incorporate into DNA, inhibit DNMT –> reexpression of silenced genes

Question 19

hypomethylating agents

examples/uses/AE

Answer 19

azacytidine
decitabine
^for tx of MDS, also AML “unfit” pts

-myelosuppression, N/V, diarrhea

Question 20

proteasome inhibitors

MOA

Answer 20

• proteosome degrades ubiquinated proteins
• inhibition prevent proteolysis of ubiquinated proteins/disruption of normal intracellular protein metabolism

*myeloma cells particularly sensitive

Question 21

proteasome inhbitors

Answer 21

bortezomib

carfilzomib

Question 22

proteasome inhbitors

AE

Answer 22

• fatigue, malaise
• N/V
• myelosuppression
• peropheral sensory neuropathy

Question 23

Immune checkpoint inhibitors

Answer 23

monoclonal Abs that block checkpoint inhibitors, thus allow T cells to recognize tumor cells

block CTLA4
block PD-1
^both found on T cells

Question 24

ipilimumab

Answer 24

-immune checkpoint inhibitor
-blocks CTLA4
AE: immune-related, enterocolitis, hepatitis, dermatitis, neuropathies, rash, pruritis, fatigue (tx immune-related AE w/ CORTICOSTEROIDS)

Question 25

pembrolizumab

nivolumab

Answer 25

PD-1 inhibitors

-immune-related AE, inc LFTs