Pharm - Biologics and Targeted Therapy Flashcards
-mab
monoclonal Ab
-omab
murine MoAb
-ximab
chimeric MoAb
-zumab
humanized MoAb
-umab
(fully) human MoAb
Rituximab
MOA
uses
anti-CD20 (NHL)
IgG
also: RA solid organ transplant rejection prevention vasculitis pemphigus
Rituximab
AE
immunosuppressive
- reactivation of hep B
- PML
- Infusion related rxns
- tumor lysis syndrome
- HAMA/HACA
- skin rxns, N/V
cetuximab
MOA/uses
- binds to cell surface of EGFR
- uses: colerectal, H and N, lung
cetuximab
AE
- infusion related rxn
- ACNEIFORM RASH
- asthenia
- N/V
- hepatotoxicity
trastuzumab
MOA/use
(herceptin)
- anti-HER2
- unconjugated, IgG
trastuzumab
AE
- infusion-related rxn
- generalized pain, asthenia, HA
- myelosuppression
- cardiotoxicity
bevacizumab
MOA
uses
- anti-VEGF
- colorectal, lung, breast, renal, wet macular degeneration
- black box warning (impaired wound healing, GI perforation, hemorrhage)
- HTN
- thombotic events
- bleeding episodes
TKIs for Bcr-Abl (CML)
AE
Imatinib
- edema, fluid retention
- cytopenias
- elevated LFTs
- cardiotoxicity
TKIs for renal cell carcinoma
AE
sunitinib
- GI, liver
- skin
“-imids”
- thalidomide
- lenalidomide
- pomalidomide
“-imids”
MOA
antiangiogenesis -inhibit basic fibroblast gfac -inhibit VEGF immunomodulatoru induce apoptosis
“-imids”
AE
- neurotoxicity
- sensory sx
- sedation
- depression
- cardio (bradycardia. peripheral edema, thrombosis)
- TERATOGEN (***thalidomide)
hypomethylating agents
MOA
(certain tumors have hypERmethylation –> silences tumor suppressors)
hypOmethylators incorporate into DNA, inhibit DNMT –> reexpression of silenced genes
hypomethylating agents
examples/uses/AE
azacytidine
decitabine
^for tx of MDS, also AML “unfit” pts
-myelosuppression, N/V, diarrhea
proteasome inhibitors
MOA
- proteosome degrades ubiquinated proteins
- inhibition prevent proteolysis of ubiquinated proteins/disruption of normal intracellular protein metabolism
*myeloma cells particularly sensitive
proteasome inhbitors
bortezomib
carfilzomib
proteasome inhbitors
AE
- fatigue, malaise
- N/V
- myelosuppression
- peropheral sensory neuropathy
Immune checkpoint inhibitors
monoclonal Abs that block checkpoint inhibitors, thus allow T cells to recognize tumor cells
block CTLA4
block PD-1
^both found on T cells
ipilimumab
-immune checkpoint inhibitor
-blocks CTLA4
AE: immune-related, enterocolitis, hepatitis, dermatitis, neuropathies, rash, pruritis, fatigue (tx immune-related AE w/ CORTICOSTEROIDS)
pembrolizumab
nivolumab
PD-1 inhibitors
-immune-related AE, inc LFTs
