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Emma Heme/Onc > General Pharm (Chemo/Alkylating&Hormones/Anti-Metabolites) > Flashcards

General Pharm (Chemo/Alkylating&Hormones/Anti-Metabolites) Flashcards

1
Q

Gompertzian Growth

A

tumor takes constant amount of time to double its size

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2
Q

Goldie-Coldman Hypothesis

A

best strategy prevention of tumor resistance is to initiate treatment early and use a combination of drugs with non-overlapping toxicities

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3
Q

Partial response to anti-cancer

A

reduction of at least 50% in the diameter of all measurable lesions

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4
Q

Stable disease

A

range from decrease of < 50% to increase of < 25% in diameter product of tumor

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5
Q

Progressive disease

A

increase of more than 25% in diameter product of any lesion

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6
Q

cell-cycle non-specific

A

alkylators
platinums
anthracyclines

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7
Q

M-phase

A

vinca alkaloids

taxanes

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8
Q

S-phase

A

antimetabolites

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9
Q

vinca alkaloids

A

vincristine, vinblastin

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10
Q

taxanes

A

paclitaxel

docetaxel

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11
Q

vomiting center (medulla) receives input from

A

GI tract, cerebral cortex, vestibular apparatus, chemoreceptor trigger zone (CTZ)

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12
Q

NTs of emetic reflex

A 
dopamine
histamine
serotonin
endorphins
ACh
GABA
Substance P
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13
Q

acute anti-emetics

A

serotonin antagonists
nk-1 antagonists
corticosteroids

(first 24hr)

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14
Q

delayed anti-emetics

A

DA antagonists
corticosteroids
nk-1 antagonists

(3-5d post chemo, assoc w/ cisplatin,
cyclophosphamide,
doxorubicin)

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15
Q

anticipatory anti-emetics

A

benzos

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16
Q

5-HT3 antagonists - anti-emetics

A

odansetron*
palonosetron*
dolasetron
granisetron

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17
Q

corticosteroid anti-emetics

A

dexmethasone

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18
Q

atypical antipsychotic - anti-emetics

A

olanzapine

19
Q

benzos - anti-emetics

A

lorazepam

20
Q

EPO to tx anemia

A

procrit

darbepoetin

21
Q

myeloid growth factors to lessen neutropenia

A

filgrastim (GCSF)
sargamostim (GM-CSF)
pegfilgrastim (long-acting GM-CSF)

22
Q

alkylating agents

A

platinum analogues

  • cisplatin
  • oxaplatin
  • carboplatin

Cyclophosphamide

Ifosfamide

23
Q

Hormonal agents - anti-cancer

A

Glucocorticoids

Androgens

24
Q

Anti-hormonal agents

A
  • aromatase inhibitors
  • anti-estrogen
  • anti-androgen
  • LH-RH agonists
25
Q

platinum analogues

A
  • cisplatin
  • oxaplatin
  • carboplatin
26
Q

standard of care w/ ifosfamide admin

A

MESNA

binds acrolein in urine

27
Q

acrolein

A

metabolite of cyclophosphamide and ifosfamide

bladder toxicity

28
Q

nitrogen mustards

A

cyclophosphamide

ifosfamide

29
Q

anti-androgens

A

flutamide
bicalutimide
nilutamide

30
Q

LHRH agonists

A

leuprolide
goserelin
triptorelin

31
Q

anti-estrogens

A

tamoxifen
raloxifene
toremifine
fulvestrant

32
Q

aromatase inhibitors

A

anastrazole
letrozole
exemestane

33
Q

glucocorticoids - anti-cancer

A

prednisone

34
Q

androgens

A

dihydrotestosterone

danazol

35
Q

anti-metabolites

A

methotrexate
cytarabine
5-FU
gemcitabine

36
Q

methotrexate reversal agent

A

leucovorin (colonic acid)

37
Q

glucarpidase

A

enzyme that rapidly cleaves methotrexate into non-toxic form

38
Q

Ara-C

A

Cytarabine

anti-metabolite

39
Q

5-FU has synergistic effects w/ _____

A

5-FU has synergistic effects w/ LEUCOVORIN

40
Q

3 intrathecal drugs

A

methotrexate
cytarabine
thiotepa

41
Q

other antimetabolites

A

6-mercaptopurine
6-thioguanine
capecitabine
pemetrexed - anti-folate

42
Q

dopamine antagonists

A

procholoperazine
metoclopramide
perphenazine

43
Q

adjuvant

A

used after deqnitive solid surgery to eradicate micro-metastatic disease

44
Q

Neoadjuvant

A

used to reduce tumor burden prior to surgical intervention

Emma Heme/Onc (16 decks)

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