Pharm/Anticoagulants

Question 1

Some drawbacks to warfarin

Answer 1

narrow TW
Slow onset
Multiple interactions
Constant monitoring required

Question 2

How do LMWH and UH compare?

Answer 2

LMW has great anti-Xa and less antiplatelet
LMW is good for prophylaxis of DVT
LMW has longer duration and doesn’t need monitoring
UH at higher risk for causing HIT

Question 3

Where does heparin bind on thrombin?

Answer 3

Exosite 2 (everything else binds to Exosite 1)

Question 4

Drawback to lepirudin?

Answer 4

Irreversible

Question 5

Lepirudin MOA

Answer 5

Direct thrombin inhibitor that doesn’t need ATIII

Question 6

HIT options?

Answer 6

Lepirudin; dabigatran

Question 7

What are some advantages to DTIs over warfarin or heparin?

Answer 7

no dose monitoring; wider TW; fewer interactions with p450

Question 8

Which drug class blocks both circulating and clot-bound thrombin?

Answer 8

DTIs

Question 9

What is dangerous about using DTIs

Answer 9

Cannot reverse effects like you can with heparin

Question 10

People with this disease should avoid warfarin

Answer 10

liver diseases

Question 11

people with this disease should avoid heparin drugs

Answer 11

renal diseases

Question 12

How would you reverse the effects of warfarin if necessary?

Answer 12

Factor replacement or plasma transfusion

Question 13

Enoxaparin MOA

Answer 13

direct anti-Xa inhibitor

Question 14

Dabigatran MOA

Answer 14

DTI

Question 15

Major side effects of dabigatran

Answer 15

dyspepsia and bleeding

Question 16

What is danaproid?

Answer 16

LMWH