Path/Transfusions

Question 1

A allele has this sugar at the end of the O antigen

Answer 1

GalNAc

Question 2

B allele has this sugar at the end of the O antigen

Answer 2

Gal

Question 3

Antibodies against foreign blood cell types are of what Ig class?

Answer 3

IgM

Question 4

What do type, screen, and crossmatch each man in context of blood bank testing?

Answer 4

Type: ABO and RH
Screen: recipient antibody screen to RBC Abs
Crossmatch: Donor cells + pt plasma, check for agglutination

Question 5

1 unit of blood high how much and raises a patient’s Hgb by how mucH?

Answer 5

250 mL, expect to see 1 g/dL rise

Question 6

What is the most common risk associated with RBC transfusion?

Answer 6

CMV seroconversion ~10%

Question 7

What are common symptoms of a hemolytic reaction?

Answer 7

Fever ~50%
Fever + chills ~ 40%
Chest pain & hypotension ~15%

Question 8

What do you do if you suspect a transfusion reaction?

Answer 8

Stop the transfusion, send the unit back along with a fresh blood sample

Question 9

The blood bank checks patient serum for signs of hemolysis. What might they see if +?

Answer 9

Pink blood –> acute hemolysis

Yellow –> chronic hemolysis

Question 10

What is the most common cause of immediate hemolytic reactions?

Answer 10

Clerical error