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OS Hematology/Oncology > Pharm/Anemia > Flashcards

Pharm/Anemia Flashcards

1
Q

Best form of oral iron

A

Ferrous

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2
Q

Deferoxamine MOA

A

Iron-chelator

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3
Q

Deferoxamine excretion & side effects

A

Urine - red

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4
Q

Acute iron overload - what do you give?

A

Deferoxamine

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5
Q

Deferoxamine side effects

A

Tachycardia, hypoT, shock

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6
Q

Deferoxamine route of admin

A

IV

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7
Q

Deferasirox indication

A

Chronic iron overload from multiple transfusions, and for acute iron overload due to ingestion

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8
Q

Deferasirox side effects

A

GI; auditory and visual disturbances; inc creatinine and hep enzymes

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9
Q

Two forms of B12 supplementation

A

Cyanocobalamin and hydroxocobalamin

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10
Q

Which form of B12 is best?

A

Hydroxocobalamin, because it is more highly protein-bound and remains longer

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11
Q

How does leucovorin interact with folic acid?

A

Reduces folate levels and rescues cells from folate antagonism (MTX); modulates effect of 5-FU

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12
Q

Levomofolate - what is it?

A

Bioactive form of folate in circulation

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13
Q

Methotrexate is liable to induce what kind of deficiency?

A

Folic acid via dihydrofolate reductase inhibition

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14
Q

How does phenytoin induce its folate deficiency?

A

Inhibits intestinal uptake

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15
Q

How does pyrimethamine induce its folate deficiency?

A

Similar to MTX, inhibits DHF reductase (not as badly though)

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16
Q

ESAs have these black box warnings

A

Chronic kidney disease and cancer (shortened survival/inc tumor progression) - use lowest dose sufficient to avoid transfusions

17
Q

G-CSF MOA

A

Stimulates G-CSF receptors on neutrophil lineage, causing stimulation of growth and diff; permits use of PBSCs by mobilizing stem cells to blood

18
Q

G-CSF and GM-CSF interact with these types of receptors

A

JAK/STAT

19
Q

GM-CSF

A

Stimulates prolif/diff of granulocyte, erythroid, and megakaryocyte progenitors (broader action than G-CSF); stimulates T-cell proliferation

20
Q

Synthetic G-CSFs

A

filgrastim, pegfilgrastim

21
Q

Synthetic GM-CSF

A

sargramostim

22
Q

Oprelvekin MOA

A

Stimulates megakaryogenesis/thrombopoiesis by binding to IL-11 receptor on megs; used to prevent thrombocytopenia

23
Q

Oprelvekin side effects

A

Fatigue, headache, dizziness, CV effects

24
Q

What is iron dextran?

A

IV form of iron

25
Q

GM-CSF side effects

A

fever, malaise, arthralgia, myalgia, peripheral edema

26
Q

GM-CSF and G-CSF - which has worse side effects?

A

GM-CSF

OS Hematology/Oncology (14 decks)

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