Path/clotting Flashcards

1
Q

PT measures these clotting moleculs

A

5, 7, 10, prothrombin, fibrinogen

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2
Q

PPT measures these clotting molecules

A

8, 9, 10, 11, 12, prothrombin, fibrinogen, HMWRK

Everything but 7

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3
Q

PT measures parts of these clotting pathways

A

extrinsic

comon

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4
Q

PPT measures parts of these clotting pathways

A

intrinsic

common

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5
Q

Which measures XIII?

A

NEITHER

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6
Q

Which measures VII?

A

PT

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7
Q

Which measures X?

A

Both

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8
Q

Which measures 11?

A

PTT

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9
Q

Which measures 4?

A

Neither

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10
Q

Which measures VII?

A

PT

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11
Q

Which measures XII?

A

PTT

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12
Q

Deficiency of this clotting factor doesn’t really result in significant bleeding

A

XII Hageman factor

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13
Q

Hemophilia inheritance

A

X

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14
Q

vWF disease inheritance

A

AD

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15
Q

What are some symptoms of vWF disease?

A

Autosomal dominant
bruising
mucous membranes
heavy periods

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16
Q

Where is vWF made?

A

Endothelium

17
Q

What is the relationship between vWF and VIII?

A

VIII does not do well in circulation without vWF

18
Q

What do vWF and hemophilia have in common?

A

Low amounts of XIII
Defect in hemophilia
in vWF, XIII dies early bc needs vWF to live

19
Q

Heparin MOA

A

Induces antithrombin III to become a more potent inhibitor of thrombin