Path/clotting

Question 1

PT measures these clotting moleculs

Answer 1

5, 7, 10, prothrombin, fibrinogen

Question 2

PPT measures these clotting molecules

Answer 2

8, 9, 10, 11, 12, prothrombin, fibrinogen, HMWRK

Everything but 7

Question 3

PT measures parts of these clotting pathways

Answer 3

extrinsic

comon

Question 4

PPT measures parts of these clotting pathways

Answer 4

intrinsic

common

Question 5

Which measures XIII?

Answer 5

NEITHER

Question 6

Which measures VII?

Answer 6

PT

Question 7

Which measures X?

Answer 7

Both

Question 8

Which measures 11?

Answer 8

PTT

Question 9

Which measures 4?

Answer 9

Neither

Question 10

Which measures VII?

Answer 10

PT

Question 11

Which measures XII?

Answer 11

PTT

Question 12

Deficiency of this clotting factor doesn’t really result in significant bleeding

Answer 12

XII Hageman factor

Question 13

Hemophilia inheritance

Answer 13

X

Question 14

vWF disease inheritance

Answer 14

AD

Question 15

What are some symptoms of vWF disease?

Answer 15

Autosomal dominant
bruising
mucous membranes
heavy periods

Question 16

Where is vWF made?

Answer 16

Endothelium

Question 17

What is the relationship between vWF and VIII?

Answer 17

VIII does not do well in circulation without vWF

Question 18

What do vWF and hemophilia have in common?

Answer 18

Low amounts of XIII
Defect in hemophilia
in vWF, XIII dies early bc needs vWF to live

Question 19

Heparin MOA

Answer 19

Induces antithrombin III to become a more potent inhibitor of thrombin