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HRR 1 > Pharm- Adrenal > Flashcards

Pharm- Adrenal Flashcards

1
Q

Short acting glucocorticoids- Names

A
  • Hydrocortisone
  • Cortisone
  • Prednisolone, prednisone, methylprednisone
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2
Q

Short acting glucocorticoids- MOA

A
  • Anti-inflammatory through AA pathway
  • Feedback inhibition on HPA axis
  • Vasoconstritive
  • Salt retaining
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3
Q

Short acting glucocorticoids- Indications

A
  • Replacement for adrenocortical deficiency
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4
Q

Short acting glucocorticoids- Duration & peak

A
  • Peak 1-2 hrs

- Duration 8-12 hrs

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5
Q

Short acting glucocorticoids- SE

A
  • Osteoporosis, cushings, cataracts, thin skin
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6
Q

Short acting glucocorticoids- Pt Ed

A

Taper off medication

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7
Q

Long action glucocorticoids- Names

A

Betamethasone, dexamethasone

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8
Q

Long action glucocorticoids- MOA

A
  • Lack sodium retention

- Mimic naturally ocurring glucocorticoids

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9
Q

Long action glucocorticoids- Indications

A
  • Cushing syndrome

- Endocrine disorders

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10
Q

Long action glucocorticoids- Duration & Peak

A
  • Peak- 1-2 hrs

- Duration; 2-3 days

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11
Q

Mineralcorticoids- Names

A

Fludrocortisone

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12
Q

Mineralcorticoids- MOA

A
  • Inhibits adrenal cortical secretion & pituitary corticotropin excretion
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13
Q

Mineralcorticoids- Indications

A
  • Addisons disease

- Andrenogential disorder

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14
Q

Mineralcorticoids- Peak & Duration

A

Peak: 1-2 hrs

- Duration 1-2 days

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15
Q

Mineralcorticoids- AE

A

Edema, brusing, impaired healing, petechiae, rash, CHF

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16
Q

Corticosteroid Tapers

A
  • Goal to avoid withdrawal
  • 7-14 days to suppress HPA axis
  • 9-12 months to restore fxn
  • slow taper, by 5 mg per day
17
Q

Acute dosing

A
  • Moderate to high dose
18
Q

Chronic dosing

A
  • Minimum dose for shortest duration
  • Morning dose best
  • Alternate days if possible
19
Q

Adjustment to stress

A
  • Raise dose to allow increased stress response

- Increased glucose availability

20
Q

Adrenal insufficiency- adjustment when ill

A
  • Double dose

- High dose for surgery, trauma, ICU

HRR 1 (12 decks)

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