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Maddy - SBL Pharm > Pharm > Flashcards

Pharm Flashcards

1
Q

what is the combination treatment for ALL (combination tx is used b/c of resistance)

A

vincristine + prednisone + ________ (6-MP, cyclophosphamide, or daunorubicin)

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2
Q

most active agent for AML

A

cytarabine

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3
Q

best combo tx for AML

A

cytarabine + idarubicin

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4
Q

combo tx for AML is followed by ______

A

high-dose chemo and total body irradiation followed by immunosuprression

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5
Q

3 first line treatments for chronic phase CML

A

imatibin, dasatibin, nilotinib

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6
Q

besides the first line tx for CML imatibin, dasatibin, nilotinib, what other drug can be used

A

busulfan

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7
Q

two regimens for CLL

A

COP: cyclophosphamide + vincristine + prednisone

CHOP: cyclophosphamide + vincristine + prednisone + doxorubicin

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8
Q

besides COP and CHOP, what agents can be used for CLL

A

bendamustine (monotherapy or w/ prednisone)

fludarabine (monotherapy or w/ cyclophosphamide and mitoxantrone)

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9
Q

regimen for hodgkin’s lymphoma stage I and IIa

A

ABVD - doxorubicin, bleomycin, vinblastine, dacarbazine

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10
Q

regimen for hodgkin’s lymphoma stage III and IV

A

MOPP: mechlorethamine, vincristine, procarbazine, prednisone

ABVD: doxorubicin, bleomycin, vinblastine, dacarbazine

Stanford V: doxorubicin, vinblastine, mechlorethamine, vincristine, bleomycin, etoposide, prednisone

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11
Q

compare MOPP, ABVD, and stanford V regimens for hodgkin’s lymphoma III and IV

A

ABVD: more effective and less toxic than MOPP

stanford V: middle best

MOPP: most adverse effects

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12
Q

regimen for diffuse non-hodgkin’s lymphoma

A

CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone

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13
Q

regimen for nodular (follicular) non-hodgkin’s lymphoma

A

bendamustine

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14
Q

regimen for multiple myeloma

A

melphalan + prednisone

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15
Q

treatment for stage 1 breast cancer

A

surgery alone

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16
Q

treatment for stage 2 breast cancer

A

post-operative:

CMF: cyclophosphamide, methotrexate, 5-FU

FAC: 5-FU, doxorubicin, cyclophosphamide

17
Q

treatment for hormone refractory prostate CA

A

docetaxel + prednisone

18
Q

regimens for high risk stage II and III colorectal CA

A

FOLFOX: leucovorin + 5-FU + oxaliplatin

XELOX: capecitabine + oxaliplatin

19
Q

regimens for metastatic colorectal cancer

A

FOLFIRI: leucovorin + 5-FU + irinotecan

FOLFIRI or FOLFOX + bevacizumab or cetuximab/panitumumab

20
Q

what agent do you use for chemo-refractory setting of colorectal cancer

A

TAS-102

21
Q

standard treatment for non-small cell lung CA with non-squamous histology

A

bevacizumab + carboplatin + paclitaxel

22
Q

treatment for non-small cell lung CA with squamous cell histology

A

cisplatin or carboplatin + cetuximab

23
Q

agent used for maintenance chemotherapy in non-small cell lung CA

A

pemetrexed

24
Q

targeted therapy for non-small cell lung CA pts with sensitizing EGFR mutations

first line tx for metastatic NSCLC w/ EGFR mutations

tx for metastatic NSCLC w/ EGFR T790 mutations

A

erlotinib

afatinib

osimertinib

25
Q

what agent is used in NSCLC that has progressed or after standard platinum-based chemo

A

nivolumab

26
Q

regimen for small cell lung cancer

A

cisplatin + etoposide

or

cisplatin + irinotecan

27
Q

what is used as second line monotherapy in small cell lung CA pts that failed platinum based regimen

A

topotecan

28
Q

tx for stage 1 ovarian CA

A

cisplatin and cyclophosphamide

29
Q

tx for stage III and IV ovarian CA

A

carboplatin and paclitaxel

30
Q

tx for recurrent dz of ovarian CA

A

topotecan or liposomal doxorubicin

31
Q

tx testicular CA

A

PEB: cisplatin + etoposide + bleomycin

32
Q

tx metastatic malignant melanoma

A

dacarbazine and cisplatin

33
Q

tx for unresectable or metastatic melanoma as monotherapy

A

nivolumab or pembrolizumab

34
Q

monotherapy and regmin tx brain cancer

A

monotherapy: carmustine
regimen: PCV: procarbazine + vincristine

35
Q

tx for adult glioblastoma multiforme

A

bevacizumab

Maddy - SBL Pharm (11 decks)

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