Pharm Flashcards
what is the combination treatment for ALL (combination tx is used b/c of resistance)
vincristine + prednisone + ________ (6-MP, cyclophosphamide, or daunorubicin)
most active agent for AML
cytarabine
best combo tx for AML
cytarabine + idarubicin
combo tx for AML is followed by ______
high-dose chemo and total body irradiation followed by immunosuprression
3 first line treatments for chronic phase CML
imatibin, dasatibin, nilotinib
besides the first line tx for CML imatibin, dasatibin, nilotinib, what other drug can be used
busulfan
two regimens for CLL
COP: cyclophosphamide + vincristine + prednisone
CHOP: cyclophosphamide + vincristine + prednisone + doxorubicin
besides COP and CHOP, what agents can be used for CLL
bendamustine (monotherapy or w/ prednisone)
fludarabine (monotherapy or w/ cyclophosphamide and mitoxantrone)
regimen for hodgkin’s lymphoma stage I and IIa
ABVD - doxorubicin, bleomycin, vinblastine, dacarbazine
regimen for hodgkin’s lymphoma stage III and IV
MOPP: mechlorethamine, vincristine, procarbazine, prednisone
ABVD: doxorubicin, bleomycin, vinblastine, dacarbazine
Stanford V: doxorubicin, vinblastine, mechlorethamine, vincristine, bleomycin, etoposide, prednisone
compare MOPP, ABVD, and stanford V regimens for hodgkin’s lymphoma III and IV
ABVD: more effective and less toxic than MOPP
stanford V: middle best
MOPP: most adverse effects
regimen for diffuse non-hodgkin’s lymphoma
CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone
regimen for nodular (follicular) non-hodgkin’s lymphoma
bendamustine
regimen for multiple myeloma
melphalan + prednisone
treatment for stage 1 breast cancer
surgery alone
treatment for stage 2 breast cancer
post-operative:
CMF: cyclophosphamide, methotrexate, 5-FU
FAC: 5-FU, doxorubicin, cyclophosphamide
treatment for hormone refractory prostate CA
docetaxel + prednisone
regimens for high risk stage II and III colorectal CA
FOLFOX: leucovorin + 5-FU + oxaliplatin
XELOX: capecitabine + oxaliplatin
regimens for metastatic colorectal cancer
FOLFIRI: leucovorin + 5-FU + irinotecan
FOLFIRI or FOLFOX + bevacizumab or cetuximab/panitumumab
what agent do you use for chemo-refractory setting of colorectal cancer
TAS-102
standard treatment for non-small cell lung CA with non-squamous histology
bevacizumab + carboplatin + paclitaxel
treatment for non-small cell lung CA with squamous cell histology
cisplatin or carboplatin + cetuximab
agent used for maintenance chemotherapy in non-small cell lung CA
pemetrexed
targeted therapy for non-small cell lung CA pts with sensitizing EGFR mutations
first line tx for metastatic NSCLC w/ EGFR mutations
tx for metastatic NSCLC w/ EGFR T790 mutations
erlotinib
afatinib
osimertinib
what agent is used in NSCLC that has progressed or after standard platinum-based chemo
nivolumab
regimen for small cell lung cancer
cisplatin + etoposide
or
cisplatin + irinotecan
what is used as second line monotherapy in small cell lung CA pts that failed platinum based regimen
topotecan
tx for stage 1 ovarian CA
cisplatin and cyclophosphamide
tx for stage III and IV ovarian CA
carboplatin and paclitaxel
tx for recurrent dz of ovarian CA
topotecan or liposomal doxorubicin
tx testicular CA
PEB: cisplatin + etoposide + bleomycin
tx metastatic malignant melanoma
dacarbazine and cisplatin
tx for unresectable or metastatic melanoma as monotherapy
nivolumab or pembrolizumab
monotherapy and regmin tx brain cancer
monotherapy: carmustine
regimen: PCV: procarbazine + vincristine
tx for adult glioblastoma multiforme
bevacizumab
