Peds Lymphoma/Leukemia Flashcards
reed sternberg cells are pathognomonic for what
what do they look like
hodgkin lymphoma
large cell with multiple or multilobulated nuclei
most common malignancy in age group 15-19
hodgkin lymphoma
what are the B symptoms used in the staging of hodgkin lymphoma
- unexplained fever 39 degrees C
- weight loss >10% total body weight over 6 months
- drenching night sweats
any patient with persistent, unexplained LAD unassociated with obvious underlying inflammatory or infectious process should undergo what
a chest x-ray to rule out mediastinal mass before undergoing lymph node biopsy
wiscott-aldrich syndrome pre-disposes patients to what dz process
non-hodgkin lymphoma
what two immune deficiencies are associated with non-hodgkin lymphoma
1) SCID
2) wiscott-aldrich syndrome
symptoms of wiscott-aldrich syndrome
- recurrent sino-pulmonary and ear infections
- severe atopic dermatitis
- bleeding
how does burkitt lymphoma often present
abdominal (sporadic type) or head and neck disease (endemic type) with involvement of the bone marrow or CNS
what is the prognosis for NHL
localized dz: 90-100% chance of survival
advanced dz: 60-95% chance
survival with NHL depends on what
1) pathologic subtype
2) tumor burden at diagnosis (reflected in LDH level)
3) presence or absence of CNS disease
4) specific sites of metastatic spread
what accounts for the greatest percentage of childhood malignancies
leukemias
what accounts for 97% of childhood leukemias
acute leukemias
pathogenesis of leukemia
malignant transformation and clonal expansion of hematopoietic cells at an early stage of differentiation that are then unable to undergo further maturation
what genetic trisomy predisposes pts to ALL and AML
trisomy 21
