Pharm Flashcards
1
Q
H-1 blockers
A
First gen
- Diphenhydramine
- Dimenhydrinate
- Chlorpheniramine
- Doxylamine
Second gen
- Loratadine
- Fexofenadine
- Desloratadine
2
Q
Guaienesin
A
Expectorant
- Thins respiratory secretions
- Does not suppress cough reflex
3
Q
N-acetylcysteine
A
- Mucolytic
- Liquifies mucus in chronic bronchopulmonary diseases (COPD, CF) by disrupting disulfide bunds
- Also used as an antidote to acetaminophen overdose
4
Q
Dextromethorphan
A
- Antitussive
- Antagonizes NMDA glutamate receptors
- Give naloxone for overdose
5
Q
Adverse effects of pseudoephedrine and phenylephrine
A
- Hypertension
- Rebound congestion if used more than 4-6 days
- CNS stimulation/anxiety (pseudoephedrine)
6
Q
Role of pseudoephedrine and phenylephrine in respiratory tract
A
Used as nasal decongestants
7
Q
Example of an endothelin receptor antagonist
A
Bosentan
8
Q
Result on inhibition of PDE-5
A
Increase in cGMP, which leads to prolonged vasodilatory effect of NO
9
Q
When are PDE-5 drugs contraindicated?
A
When taking nitroglycerin or other nitrates, due to risk of sever hypotension
10
Q
Side effects of prostacyclin analogs
A
Flushing
Jaw pain
11
Q
Examples of prostacylin analogs
A
Epoprostenol
iloprost
12
Q
Toxicity of zileuton
A
Hepatotoxic
13
Q
When is omalizumab used?
A
In allergic asthma, with increased IgE levels resistant to inhaled steroids and long-acting B2-agonists
