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OS3 > Lectures Pulm > Flashcards

Lectures Pulm Flashcards

1
Q

Where does bronchiectasis occur in kartagener’s syndrome? CF?

A

Kartagener’s: Lower lobes

CF: Upper lobes

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2
Q

Goodpasture’s demographic

A

Men and smokers

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3
Q

Lung findings in Goodpasture’s sydrome

A

Hemorrhagic necrotizing interstitial pneumonities

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4
Q

Goodpasture’s treatment

A

Plasmapheresis

Immunosuppressive therapy

Renal transplantation

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5
Q

Major risk factors for community acquired pneumonia

A

COPD

Ig defects

Asplenia

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6
Q

Inflammatory mediators involved in chronic bronchitis

A

Histamine

IL-13

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7
Q

What are the 3 phases of Churg-Strauss Syndrome?

A
  • Allergic- asthma and/or allergic rhinitis
  • Eosinophilic
  • Vasculitic- tissue damage in various organs
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8
Q

Churg-Strauss antibodies

A
  • MPO in case of p-ANCA
  • PR3 (proteinase) in case of c-ANCA
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9
Q

Triad of Wegener’s Granulomatosis

A
  • Acute necrotizing granulomas of the upper and lower respiratory tract or both
  • Necrotizing or granulomatous vasculitis
  • Renal disease
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10
Q

Antibodies Wegener’s

A

c-ANCA (anti PR3)

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11
Q

HLA association of Good pastures

A

HLA-DRB1

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12
Q

Treatment for Good pastures

A

Plasma exhange

Immunosuppresion

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13
Q

Most common associations with spontaneous pneumothorax

A

Emphysema

Asthma

TB

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14
Q
  • CD34+, keratin neg
  • NAB2-STAT6 fusion gene
  • Chromosome 12
  • Pleural Tumor
A

Solitary fibrous tumor

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15
Q

Positive stains for mesothelioma

A
  • Calretinin
  • WT-1
  • CK 5/6
  • D2-40
  • Keratins
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16
Q

Paraneoplastic disorder: Clubbing. Malignancy?

A

Adenocarcinoma

17
Q

Paraneoplastic disorder: Dermatomyositis. Malignancy?

A

Small cell carcinoma

18
Q

Paraneoplastic disorder: Venous thrombosis (trousseau phenomenon). Malignancy?

A

Adenocarcinoma

19
Q

CK7

TTF-1

Napsin A

A

Adenocarcinoma

20
Q

P63

CK5/6

A

Squamous cell carcinoma

21
Q

Synaptophysin

Chromogranin

CD 56

NSE

A

Neuroendocrine tumors

22
Q

Metronidazole mechanism of action

A

Production of free radicals toxic to microbes

23
Q

Mechanism of action of dactomycin

A

Calcium-dependent depolarization of the bacterial cell wall, by causing potassium efflux

OS3 (10 decks)

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