Pharm Flashcards

1
Q

Reverse toxicity of Acetaminophen

A

N-acetylcysteine (replenishes glutathione)

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2
Q

Reverse toxicity of AChE inhibitors, organophosphates

A

Atropine > pralidoxime

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3
Q

Reverse toxicity of Antimuscarinic, anticholinergic agents

A

Physostigmine, control hyperthermia

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4
Q

Reverse toxicity of Arsenic

A

Dimercaprol, succimer

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5
Q

Reverse toxicity of Benzodiazepines

A

Flumazenil

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6
Q

Reverse toxicity of β-blockers

A

Atropine, glucagon

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7
Q

Reverse toxicity of Carbon monoxide

A

100% O2, hyperbaric O2

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8
Q

Reverse toxicity of Copper

A

Penicillamine, trientine (Copper penny)

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9
Q

Reverse toxicity of Cyanide

A

Nitrite + thiosulfate, hydroxocobalamin

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10
Q

Reverse toxicity of Digitalis (digoxin)

A

Anti-dig Fab fragments

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11
Q

Reverse toxicity of Heparin

A

Protamine sulfate

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12
Q

Reverse toxicity of Iron

A

Deferoxamine, deferasirox, deferiprone

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13
Q

Reverse toxicity of Mercury

A

Dimercaprol, succimer

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14
Q

Reverse toxicity of Methanol, ethylene glycol (antifreeze)

A

Fomepizole > ethanol, dialysis

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15
Q

Reverse toxicity of Methemoglobin

A

Methylene blue, vitamin C

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16
Q

Reverse toxicity of Opioids

A

Naloxone

17
Q

Reverse toxicity of Salicylates

A

NaHCO3 (alkalinize urine), dialysis

18
Q

Reverse toxicity of TCAs

A

NaHCO3

19
Q

Reverse toxicity of Warfarin

A
Vitamin K (delayed effect), fresh frozen plasma
(immediate)
20
Q

How many 1/2 lives to reach steady state in first order kinetics?

A

4-5