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FA note cards > Immuno > Flashcards

Immuno Flashcards

1
Q

Site of B-cell localization and proliferation

A

Follicle

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2
Q

Underdeveloped in DiGeorge

A

Paracortex

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3
Q

Site of T-cell differentiation and maturation

A

Thymus

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4
Q

HLA associated with Hemochromatosis

A

A3

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5
Q

HLA associated with Addison disease, myasthenia gravis, Graves
disease

A

B8

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6
Q

HLA associated with Psoriatic arthritis, Ankylosing spondylitis, IBD-associated arthritis, Reactive arthritis

A

B27

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7
Q

HLA associated with Celiac disease

A

DQ 2 and 8

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8
Q

HLA associated with Multiple sclerosis, hay fever, SLE, Goodpasture syndrome

A

DR2

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9
Q

HLA associated withDiabetes mellitus type 1, SLE, Graves disease, Hashimoto thyroiditis, Addison disease

A

DR3

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10
Q

HLA associated with Rheumatoid arthritis, diabetes mellitus type 1, Addison disease

A

DR4

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11
Q

IPEX

A

(Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked) syndrome
-Genetic deficiency of FOXP3 (defective Regulatory T cells) autoimmunity
Characterized by enteropathy, endocrinopathy, nail dystrophy, dermatitis, and/or other autoimmune dermatologic conditions. Associated with diabetes in male infants

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12
Q

C3 deficiency

A

↑ risk of severe, recurrent pyogenic sinus and respiratory tract infections: incr susceptibility to T3HS

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13
Q

CD55 deficiency

A

Also called decay-accelerating factor (DAF) deficiency.

Causes complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

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14
Q

T1 HS

A

Anaphylaxis
Test: skin test or blood test (ELISA) for allergenspecific
IgE

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15
Q

T2 HS

A 
Autoimmune-hemolytic anemia
Immune thrombocytopenic purpura
Transfusion reactions
Hemolytic disease of the newborn
Goodpasture syndrome
Rheumatic fever
Hyperacute transplant rejection
Myasthenia gravis
Graves disease
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16
Q

T3 HS

A

SLE
Polyarteritis nodosa
Poststreptococcal glomerulonephritis

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17
Q

T4 HS

A 
Type 1 diabetes mellitus
Contact dermatitis (eg, poison ivy, nickel
allergy)
Graft-versus-host disease
PPD
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18
Q

Febrile nonhemolytic transfusion reaction

A

T2HS
Host antibodies against donor HLA antigens and WBC
Within 1–6 hours

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19
Q

Acute hemolytic transfusion reaction

A 
T2HS
Intravascular hemolysis (ABO blood group incompatibility) or extravascular hemolysis (host antibody reaction against
foreign antigen on donor RBCs)
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20
Q

Transfusion-related acute lung injury

A

Donor anti-leukocyte antibodies against recipient neutrophils and pulmonary endothelial cells

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21
Q

Anti-ACh receptor

A

Myasthenia gravis

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22
Q

Anti-glomerular basement membrane

A

Goodpasture syndrome

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23
Q

Anti-β2 glycoprotein

A

Antiphospholipid syndrome

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24
Q

Anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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25
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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26
Q

Anti-desmoglein (anti-desmosome)

A

Pemphigus vulgaris

27
Q

Anti-glutamic acid decarboxylase, islet cell

cytoplasmic antibodies

28
Q

Anti-hemidesmosome

A

Bullous pemphigoid

29
Q

Antisynthetase (eg, anti-Jo-1), anti-SRP, antihelicase (anti-Mi-2)

A

Polymyositis, dermatomyositis

30
Q

Antimicrosomal, antithyroglobulin, anti-thyroid peroxidase

A

Hashimoto thyroiditis

31
Q

Antimitochondrial

A

1° biliary cirrhosis

32
Q

Antiparietal cell, anti-intrinsic factor

A

Pernicious anemia

33
Q

Antiphospholipase A2 receptor

A

1° membranous nephropathy

34
Q

Anti-Scl-70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

35
Q

Anti-smooth muscle

A

Autoimmune hepatitis type 1

36
Q

Anti-SSA, anti-SSB (anti-Ro, anti-La)

A

Sjögren syndrome

37
Q

Anti-TSH receptor

A

Graves disease

38
Q

Anti-presynaptic voltage-gated calcium channel

A

Lambert-Eaton myasthenic syndrome

39
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase

A

Celiac disease

40
Q

MPO-ANCA/p-ANCA

A

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), ulcerative colitis

41
Q

PR3-ANCA/c-ANCA

A

Granulomatosis with polyangiitis (Wegener)

42
Q

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific)

A

Rheumatoid arthritis

43
Q

Antinuclear (ANA)

A

Nonspecific screening antibody, often associated with SLE

44
Q

Anti-dsDNA, anti-Smith Anti-histone

A

SLE, drug induced SLE

45
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

46
Q

X-linked (Bruton) agammaglobulinemia

A

XR; B-cell disorder
Defect in BTK, a tyrosine kinase gene: no B-cell maturation
Dear Ig of all classes; Absent/scanty lymph nodes and tonsils

47
Q

Selective IgA deficiency

A

Decr IgA
Incr susceptibility to giardiasis
Airway and GI infections, Autoimmune disease, Atopy, Anaphylaxis to IgA-containing products

48
Q

Common variable immunodeficiency

A

Defect in B-cell differentiation

49
Q

DiGeorge syndrome

A
  • Thymic aplasia
  • 22q11 deletion; failure to develop 3rd and 4th pharyngeal pouches: absent thymus and parathyroids
  • Tetany (hypocalcemia), recurrent viral/fungal infections (T-cell deficiency), conotruncal abnormalities
50
Q

IL-12 receptor deficiency

A

↓ Th1 response, dear IFN-gamma

51
Q

Autosomal dominant hyper-IgE syndrome

A

Job Syndrome
Deficiency of Th17 cells due to STAT3 mutation -> impaired recruitment of neutrophils to sites of infection
Incr IgE, decr IFN-gamma

52
Q

Ataxia-telangiectasia

A

Cerebellar defects (Ataxia), spider Angiomas (telangiectasia), IgA deficiency
↑ AFP, risk of lymphoma and leukemia
Decr IgA, IgG and IgE

53
Q

Hyper-IgM syndrome

A

Defective CD40L on Th cells; no class switching

54
Q

Wiskott-Aldrich syndrome

A

Mutation in WASp gene; leukocytes and platelets unable to reorganize actin cytoskeleton; defective antigen presentation
↑ IgE and IgA

55
Q

Leukocyte adhesion deficiency (type 1)

A

Defect in LFA-1 integrin(CD18) protein on phagocytes; impaired migration and chemotaxis; autosomal recessive
↑ neutrophils

56
Q

Chédiak-Higashi syndrome

A

-Defect in lysosomal trafficking regulator gene (LYST)
Microtubule dysfunction in phagosome lysosome fusion; autosomal recessive
-Recurrent pyogenic infections by staphylococci and streptococci, partial albinism, peripheral neuropathy, progressive
neurodegeneration, infiltrative lymphohistiocytosis.

57
Q

Chronic granulomatous disease diagnosis

A 
Abnormal dihydrorhodamine (flow cytometry) test
Nitroblue tetrazolium dye reduction test (obsolete) fails to turn blue
58
Q

What is CREST?

A

Calcinosis, Raynaud, Esophageal dysmotility, Sclerodactyly, Telangiectasia

59
Q

Role of CD8 cells

A

Kill virally infected cells

60
Q

Drugs with zero order kinetics

A

Phenytoin, ethanol, salicylates, fluoxetine, omeprazole, and cisplatin

61
Q

The Pygmalion effect

A

Phenomenon of groups altering their outcomes to meet external expectations

62
Q

Chapman’s point for the bladder

A

Periumbilical

63
Q

SCID

A

IL2-R or ADA deficiency
TtF, diarrhea, thrush, all infection type
No thymic shadow

FA note cards (16 decks)

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