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Immuno Flashcards

1
Q

Site of B-cell localization and proliferation

A

Follicle

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2
Q

Underdeveloped in DiGeorge

A

Paracortex

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3
Q

Site of T-cell differentiation and maturation

A

Thymus

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4
Q

HLA associated with Hemochromatosis

A

A3

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5
Q

HLA associated with Addison disease, myasthenia gravis, Graves
disease

A

B8

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6
Q

HLA associated with Psoriatic arthritis, Ankylosing spondylitis, IBD-associated arthritis, Reactive arthritis

A

B27

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7
Q

HLA associated with Celiac disease

A

DQ 2 and 8

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8
Q

HLA associated with Multiple sclerosis, hay fever, SLE, Goodpasture syndrome

A

DR2

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9
Q

HLA associated withDiabetes mellitus type 1, SLE, Graves disease, Hashimoto thyroiditis, Addison disease

A

DR3

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10
Q

HLA associated with Rheumatoid arthritis, diabetes mellitus type 1, Addison disease

A

DR4

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11
Q

IPEX

A

(Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked) syndrome
-Genetic deficiency of FOXP3 (defective Regulatory T cells) autoimmunity
Characterized by enteropathy, endocrinopathy, nail dystrophy, dermatitis, and/or other autoimmune dermatologic conditions. Associated with diabetes in male infants

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12
Q

C3 deficiency

A

↑ risk of severe, recurrent pyogenic sinus and respiratory tract infections: incr susceptibility to T3HS

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13
Q

CD55 deficiency

A

Also called decay-accelerating factor (DAF) deficiency.

Causes complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria

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14
Q

T1 HS

A

Anaphylaxis
Test: skin test or blood test (ELISA) for allergenspecific
IgE

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15
Q

T2 HS

A 
Autoimmune-hemolytic anemia
Immune thrombocytopenic purpura
Transfusion reactions
Hemolytic disease of the newborn
Goodpasture syndrome
Rheumatic fever
Hyperacute transplant rejection
Myasthenia gravis
Graves disease
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16
Q

T3 HS

A

SLE
Polyarteritis nodosa
Poststreptococcal glomerulonephritis

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17
Q

T4 HS

A 
Type 1 diabetes mellitus
Contact dermatitis (eg, poison ivy, nickel
allergy)
Graft-versus-host disease
PPD
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18
Q

Febrile nonhemolytic transfusion reaction

A

T2HS
Host antibodies against donor HLA antigens and WBC
Within 1–6 hours

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19
Q

Acute hemolytic transfusion reaction

A 
T2HS
Intravascular hemolysis (ABO blood group incompatibility) or extravascular hemolysis (host antibody reaction against
foreign antigen on donor RBCs)
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20
Q

Transfusion-related acute lung injury

A

Donor anti-leukocyte antibodies against recipient neutrophils and pulmonary endothelial cells

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21
Q

Anti-ACh receptor

A

Myasthenia gravis

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22
Q

Anti-glomerular basement membrane

A

Goodpasture syndrome

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23
Q

Anti-β2 glycoprotein

A

Antiphospholipid syndrome

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24
Q

Anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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25
Anticentromere
Limited scleroderma (CREST syndrome)
26
Anti-desmoglein (anti-desmosome)
Pemphigus vulgaris
27
Anti-glutamic acid decarboxylase, islet cell | cytoplasmic antibodies
T1 DM
28
Anti-hemidesmosome
Bullous pemphigoid
29
Antisynthetase (eg, anti-Jo-1), anti-SRP, antihelicase (anti-Mi-2)
Polymyositis, dermatomyositis
30
Antimicrosomal, antithyroglobulin, anti-thyroid peroxidase
Hashimoto thyroiditis
31
Antimitochondrial
1° biliary cirrhosis
32
Antiparietal cell, anti-intrinsic factor
Pernicious anemia
33
Antiphospholipase A2 receptor
1° membranous nephropathy
34
Anti-Scl-70 (anti-DNA topoisomerase I)
Scleroderma (diffuse)
35
Anti-smooth muscle
Autoimmune hepatitis type 1
36
Anti-SSA, anti-SSB (anti-Ro, anti-La)
Sjögren syndrome
37
Anti-TSH receptor
Graves disease
38
Anti-presynaptic voltage-gated calcium channel
Lambert-Eaton myasthenic syndrome
39
IgA anti-endomysial, IgA anti-tissue transglutaminase
Celiac disease
40
MPO-ANCA/p-ANCA
Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), ulcerative colitis
41
PR3-ANCA/c-ANCA
Granulomatosis with polyangiitis (Wegener)
42
Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific)
Rheumatoid arthritis
43
Antinuclear (ANA)
Nonspecific screening antibody, often associated with SLE
44
Anti-dsDNA, anti-Smith Anti-histone
SLE, drug induced SLE
45
Anti-U1 RNP (ribonucleoprotein)
Mixed connective tissue disease
46
X-linked (Bruton) agammaglobulinemia
XR; B-cell disorder Defect in BTK, a tyrosine kinase gene: no B-cell maturation Dear Ig of all classes; Absent/scanty lymph nodes and tonsils
47
Selective IgA deficiency
Decr IgA Incr susceptibility to giardiasis Airway and GI infections, Autoimmune disease, Atopy, Anaphylaxis to IgA-containing products
48
Common variable immunodeficiency
Defect in B-cell differentiation
49
DiGeorge syndrome
- Thymic aplasia - 22q11 deletion; failure to develop 3rd and 4th pharyngeal pouches: absent thymus and parathyroids - Tetany (hypocalcemia), recurrent viral/fungal infections (T-cell deficiency), conotruncal abnormalities
50
IL-12 receptor deficiency
↓ Th1 response, dear IFN-gamma
51
Autosomal dominant hyper-IgE syndrome
Job Syndrome Deficiency of Th17 cells due to STAT3 mutation -> impaired recruitment of neutrophils to sites of infection Incr IgE, decr IFN-gamma
52
Ataxia-telangiectasia
Cerebellar defects (Ataxia), spider Angiomas (telangiectasia), IgA deficiency ↑ AFP, risk of lymphoma and leukemia Decr IgA, IgG and IgE
53
Hyper-IgM syndrome
Defective CD40L on Th cells; no class switching
54
Wiskott-Aldrich syndrome
Mutation in WASp gene; leukocytes and platelets unable to reorganize actin cytoskeleton; defective antigen presentation ↑ IgE and IgA
55
Leukocyte adhesion deficiency (type 1)
Defect in LFA-1 integrin(CD18) protein on phagocytes; impaired migration and chemotaxis; autosomal recessive ↑ neutrophils
56
Chédiak-Higashi syndrome
-Defect in lysosomal trafficking regulator gene (LYST) Microtubule dysfunction in phagosome lysosome fusion; autosomal recessive -Recurrent pyogenic infections by staphylococci and streptococci, partial albinism, peripheral neuropathy, progressive neurodegeneration, infiltrative lymphohistiocytosis.
57
Chronic granulomatous disease diagnosis
``` Abnormal dihydrorhodamine (flow cytometry) test Nitroblue tetrazolium dye reduction test (obsolete) fails to turn blue ```
58
What is CREST?
Calcinosis, Raynaud, Esophageal dysmotility, Sclerodactyly, Telangiectasia
59
Role of CD8 cells
Kill virally infected cells
60
Drugs with zero order kinetics
Phenytoin, ethanol, salicylates, fluoxetine, omeprazole, and cisplatin
61
The Pygmalion effect
Phenomenon of groups altering their outcomes to meet external expectations
62
Chapman's point for the bladder
Periumbilical
63
SCID
IL2-R or ADA deficiency TtF, diarrhea, thrush, all infection type No thymic shadow

FA note cards (16 decks)

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