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AII 4 > Pharm > Flashcards

Pharm Flashcards

1
Q

Metronidazole- MOA

A

Acts as an electron acceptor forming cytotoxic compounds-> cell death

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2
Q

Metronidazole- Uses

A

ameobas, giardia, trichamonas, anaerobic cocci & Gram - bacilli,

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3
Q

Metronidazole- Adverse Effects

A

GI- N/V metallic taste, yeast infection of mouth, numbness & paraesthsias. Don’t take with alcohol!

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4
Q

Metronidazole- Drug interactions

A

Alcohol- aldehyde dehydrogenase inhibitor, alters GI flora & lowers seizure threshold.

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5
Q

Chloroquine- Indications

A

Eliminates trophozites in liver abscess & malaria.

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6
Q

Chloroquine- MOA

A

Binds to parasitized erythrocytes causing cell lysis

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7
Q

Chloroquine- Drug interactions

A

CYP 450, photo sensativity, lower seizure threshold

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8
Q

Chloroquine- SE

A

N/V/D, retinal and macular problems

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9
Q

Mebendazole- Indications

A

Nematodes- whipworm, hookworm, roundworm, pinworm

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10
Q

Mebendazole- MOA

A

interferes with microtubule assembly in parasite & decreases glucose uptake

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11
Q

Mebendazole- SE

A

Embryotoxic & teratogenic, abd pain, diarrhea

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12
Q

Mebendazole- Drug interactions

A

None

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13
Q

Pyrantel pamoate- Indications

A

In conjunction with mebendazole eliminates round, pin & hook worms

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14
Q

pyrantel pamoate- MOA

A

Blocks parasitic nicotinic receptors causing paralysis

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15
Q

pyrantel pamoate- AE

A

N/V/D

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16
Q

pyrantel pamoate- Drug interactions

A

None

17
Q

Lindane lotion- Indications

A

Scabies, pediculosis

18
Q

Lindane lotion- MOA

A

Directly absorbed by ova & parasites

19
Q

Lindane lotion- AE

A

dizziness, dermatitis, neurotoxicity, seizures

20
Q

Lindane lotion- Drug Interactions

A

Lowers seizure threshold

21
Q

Permethrin- Indications

A

Scabies & lice (head & pubic)

22
Q

Permethrin- MOA

A

Alters cell membrane function- pediculicide

23
Q

Permethrin- AE

A

Burning, itching, erythema, numbness

AII 4 (10 decks)

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