Pharm 21: Lasik make pee Flashcards
ADH MOA
Constricts vasculature and promotes water reabsorption via G-protein receptors
V1: vascular smooth muscle contriction
V2: collecting duct of principal cells
ADH V2 activity (MOA)
Gs g-protein
CAMP increases ->protein kinase A (PKA) increases
PKA increases aquaporin 2 activity
Aliskiren MOA and use
Renin inhibitor. Binds to active site inhibiting the binding of renin
Used for hypertension with renal insufficiency
Can be used w/ thiazides
Kinin levels w/ ACE inhibitors
Are increased
ACE inhibitors metabolism patterns
1) Captopril. Active, biotransformed to active metabolite
2) Enalapril/ Ramipril: prodrug. if at suffix then active
3) Lisinopril: active form, excreted unchanged by kidney
ACE inhibitor cough angioedema because
Potentiation of bradykinin
ACE inhibitors and potassium
Reduced aldosterone synthesis causes hyperK
Losartan and Valsartan MOA
AT1 receptor antagonist. —> Angotensin II inhibition
AT1 receptor antagonist vs ACE inhibittor
AT1 more complete angiotensin II inhibition, but no vasodilation
Nesiritide MOA and use
Recombinant BNP
Short term decompensated HF
Demclocycline MOA and use
MOA unk
Use for SIADH
tretracycline *
Conivaptan/tolvaptan MOA and use
V1/V2 (vasopressin) receptor antagonists
Tolvaptan is oral
use in SIADH and nephrogenic diabetes insipidus
Acetalozimide MOA
inhibit sodium reabsorption by noncompetitively and reversibly inhibiting carbonic anhydrase in proximal tubule cells
Acetazolimide compensation
NaCl and NaHCO3 reabsorption increases after some days
Acetozolamide uses
Mountain sickness, times when urine alkanization is needed