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pharm 201 E4 Flashcards

1
Q

Leflunomide MOA/Tx

A

Immunosuppressant/RA

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2
Q

Leflunomide AE

A

Infection, bone marrow suppression, hepatotoxicity

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3
Q

Leflunomide Contra

A

liver failure, ETOHism, blood dyscrasias

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4
Q

Leflunomide Nsg

A

May take 3-6 weeks to see full effects, monitor LFTs, ususally 2nd in line to mehotrexate

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5
Q

Sulfasalazine AE

A

GI rxns, rash, hepatitis, bone marrow suppression

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6
Q

Sulfasalazine Contra

A

*Sulfa and salicylate allergies

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7
Q

Sulfasalazine Nsg

A

EC tabs, in divided doses help GI rxns, monitor LFTs and platelets

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8
Q

Etanercept MOA/Tx

A

Bioologic DMARD, targets inflammatory process/RA

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9
Q

Etanercept AE

A

Infections (TB or sore throat and fever), injection site rxn

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10
Q

Etanercept Nsg

A

Sub-Q injection, should be clear w/o particles present

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11
Q

Glucocorticoids in RA

A

Anti-inflammatory that slows disease progression

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12
Q

Glucocorticoids in RA AE

A

Infection

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13
Q

Most common glucocorticoids in RA

A

Predisone, prednisolone

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14
Q

Methotrexate MOA/Tx

A

Non-biologic DMARD/RA

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15
Q

Methotrexate AE

A

*Bone marrow suppression, infection, hepatotoxicity

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16
Q

Methotrexate Contra

A

liver failure, ETOHism, blood dyscrasias

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17
Q

Methotrexate Nsg

A

*May take 3-6 weeks to see effects of drug (don’t quit), report abd fullness/jaundice

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18
Q

Hydroxychloroquine MOA/Tx

A

Non-biologic DMARD/RA

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19
Q

Hydroxychloroquine AE

A

*Retinal damage

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20
Q

Hydroxychloroquine Contra

A

Retinal/visual field changes, pregnancy

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21
Q

Hydroxychloroquine Nsg

A

*Get baseline from optomotrist before starting Tx, will NOT slow disease progression

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22
Q

Allopurinol MOA/Tx

A

Decreases production of uric acid/Gout

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23
Q

Allopurinol AE

A

*Bone marrow suppression (looks like leukemia), rash, hepatotoxic

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24
Q

Allopurinol Contra

A

Impaired renal/liver fxn

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25
Allopurinol Nsg
Alkaline-ash diet, no ETOH, increase fluids
26
Colchicine MOA/Tx
Anti-inflammatory for gout/Gout
27
Colchicine AE
Abd pain, N/V/D (common)
28
Colchicine Contra
Sever GI disorders, hepatic/renal impairment
29
Colchicine Nsg
*Alkaline-ash diet, take w/ food, avoid fish (purine)
30
Probenecid MOA/Tx
Increases uric acid excretion/Gout
31
Probenecid AE
GI rxn, renal injury
32
Probenecid Contra
*Do NOT use concurrently with salicylates (bleeding)
33
Probenecid Nsg
Take w/ food, increase fluids
34
Cyclosporine MOA/Tx
Inhibits T-lymphocytes (immunosuppressant)/Organ rejection
35
Cyclosporine AE
*Hirsutism, nephrotoxicity, infection
36
Cyclosporine Nsg
*Do not give w/ "azole" drugs (CYP-450), monitor for infection
37
Glucocorticoids in Immune Tx
Organ rejection
38
Glucocorticoids in Immune AE
Cushing's disease, glucose intolerance, infection
39
Glucocorticoids in Immune Nsg
Accumulate in body
40
Azathioprine MOA/Tx
Inhibits B and T lymphocytes (immunosuppressant)/Adjunct to help suppress organ rejection
41
Azathioprine AE
*Bone marrow suppression (causes thrombocytopenia and neutropenia)
42
Azathioprine Nsg
Monitor PT/INR
43
Mycophenolate MOA/Tx
Inhibits B and T cell proliferation/Organ rejection
44
Mycophenolate AE
*Sepsis. GI rxns, neutropenia
45
Mycophenolate Nsg
*Doses are blood level dependent and MUST be given on time
46
Tacrolimus MOA/Tx
Inhibits T-lymphocyte activation/Organ rejection
47
Tacrolimus AE
Nephrotoxic, GI rxns, infection
48
Tacrolimus Nsg
Dosage is weight based according to organ transplanted
49
Didanosine MOA/Tx
First line antiviral/HIV
50
Didanosine AE
Lactic acidosis, hepatotoxic
51
Didanosine Nsg
* Take on empty stomach (30 min before or 2 hrs after meal) | * Only to tx HIV
52
Efavirenz MOA/Tx
NNRTI/HIV
53
Efavirenz AE
*Rash (adults 27% children 40%), CNS symptoms (~50% of pts will have this)
54
Efavirenz Nsg
Do not skip doses, Monitor for rash (SJS)
55
Zidovudine MOA/Tx
NRTI/HIV
56
Zidovudine AE
*Bone marrow suppression, lactic acidosis, hepatomegaly
57
Zidovudine Contra
Caution in liver disease and bone marrow suppression
58
Zidovudine Nsg
Monitor all tests having to do with liver and blood
59
Lopinavir/Ritonavir MOA/Tx
Protease inhibitor/HIV
60
Lopinavir/Ritonavir AE
Hyperglycemia, osteoporosis, pseudo-cushings syndrome, N/V/D, HA
61
Lopinavir/Ritonavir Contra
Breastfeeding
62
Lopinavir/Ritonavir Nsg
Report s/s of DI, caution in liver disease, CYP-450
63
Enfuvirtide MOA/Tx
Blocks entry into CD4 cells/HIV
64
Enfuvirtide AE
*Injection site reaction, bacterial pneumonia
65
Enfuvirtide Nsg
Sub-Q injection BID, rotate sites, monitor for bacterial pneumonia
66
Doxorubicin MOA/Tx
Anthracycline/Antitumor abx(chemo)
67
Doxorubicin AE
Red coloration to urine/sweat, acute cardiac toxicity, dysrhythmias, HF
68
Doxorubicin Contra
Severe myelosuppression, and a lifetime cumulative dose of 550 mg/m^2, prego cat D
69
Doxorubicin Nsg
Monitor ECG/cardiac fxn, f/u appt. to screen for delayed cardiac toxicity, pt should notify HCP of chest pain/SOB
70
Carmustine MOA/Tx
Nitrosureas/Chemo
71
Carmustine AE
Pulmonary fibrosis, liver and kidney toxicity
72
Carmustine Contra
Severe myelosuppression, impaired pulmonary fxn, prego cat D
73
Carmustine Nsg
Encourage fluids, monitor for bleeding/infection
74
Cyclophosphamide MOA/Tx
Nitrogen Mustards/Chemo
75
Cyclophosphamide AE
Bone marrow suppression, bleeding
76
Cyclophophamide Contra
Sever myelosuppression, caution in w/ kidney/liver disorders
77
Cyclophosphamide Nsg
Encourage fluids, monitor bleeding/infection
78
Cisplatin MOA/Tx
Platinum compound/Chemo
79
Cisplatin AE
*Hearing loss, renal toxicity
80
Cisplatin Contra
Hearing loss, severe myelpsuppression, kidney disorders
81
Cisplatin Nsg
*Monitor hearing prior to tx, encourage fluids, monitor bleeding/infection
82
Interferon MOA/Tx
Biological response modifier/Chemo
83
Interferon AE
Flu-like s/s, bone marrow suppression, depression
84
Interferon Contra
Suicidal thoughts, colitis, pancreatitis, caution in liver/kidney/heart/lung disease/DM/depression
85
Interferon Nsg
Store in refrigerator (Do not freeze) and admin at room temp, monitor: flu s/s, CBC, platelets, e-, and fluid status
86
Leuprolide MOA/Tx
GRHA/Prostate CA
87
Leuprolide AE
Hot flashes, decreased libido, gynecomastia, decreased bone density, arrhythmias, pulmonary edema
88
Leuprolide Contra
Prego cat X
89
Leuprolide Nsg
Increase Ca and Vit D intake, encourage weight-bearing exercise, prostate symptoms may worsen at beginning of Tx, Monitor: PSA, testosterone levels, arrhythmias, breath sounds
90
Tamoxifen MOA/Tx
Hormonal agent/Breast CA
91
Tamoxifen AE
Endometrial CA, HyperCa, N/V, pulmonary embolus, hot flashes, vaginal discharge/bleeding
92
Tamoxifen Contra
Pt taking warfarin or w/ Hx of blood clots/pulmonary embolism, prego cat D
93
Tamoxifen Nsg
Increase Ca and vit D intake, encourage weight-bearing exercise, preform monthly BSE and annual exams w/ provider, use birth control during therapy

Pharmacology 2 (5 decks)

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