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Pharmacology 2 > pharm 201 E4 > Flashcards

pharm 201 E4 Flashcards

1
Q

Leflunomide MOA/Tx

A

Immunosuppressant/RA

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2
Q

Leflunomide AE

A

Infection, bone marrow suppression, hepatotoxicity

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3
Q

Leflunomide Contra

A

liver failure, ETOHism, blood dyscrasias

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4
Q

Leflunomide Nsg

A

May take 3-6 weeks to see full effects, monitor LFTs, ususally 2nd in line to mehotrexate

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5
Q

Sulfasalazine AE

A

GI rxns, rash, hepatitis, bone marrow suppression

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6
Q

Sulfasalazine Contra

A

*Sulfa and salicylate allergies

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7
Q

Sulfasalazine Nsg

A

EC tabs, in divided doses help GI rxns, monitor LFTs and platelets

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8
Q

Etanercept MOA/Tx

A

Bioologic DMARD, targets inflammatory process/RA

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9
Q

Etanercept AE

A

Infections (TB or sore throat and fever), injection site rxn

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10
Q

Etanercept Nsg

A

Sub-Q injection, should be clear w/o particles present

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11
Q

Glucocorticoids in RA

A

Anti-inflammatory that slows disease progression

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12
Q

Glucocorticoids in RA AE

A

Infection

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13
Q

Most common glucocorticoids in RA

A

Predisone, prednisolone

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14
Q

Methotrexate MOA/Tx

A

Non-biologic DMARD/RA

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15
Q

Methotrexate AE

A

*Bone marrow suppression, infection, hepatotoxicity

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16
Q

Methotrexate Contra

A

liver failure, ETOHism, blood dyscrasias

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17
Q

Methotrexate Nsg

A

*May take 3-6 weeks to see effects of drug (don’t quit), report abd fullness/jaundice

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18
Q

Hydroxychloroquine MOA/Tx

A

Non-biologic DMARD/RA

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19
Q

Hydroxychloroquine AE

A

*Retinal damage

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20
Q

Hydroxychloroquine Contra

A

Retinal/visual field changes, pregnancy

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21
Q

Hydroxychloroquine Nsg

A

*Get baseline from optomotrist before starting Tx, will NOT slow disease progression

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22
Q

Allopurinol MOA/Tx

A

Decreases production of uric acid/Gout

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23
Q

Allopurinol AE

A

*Bone marrow suppression (looks like leukemia), rash, hepatotoxic

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24
Q

Allopurinol Contra

A

Impaired renal/liver fxn

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25
Q

Allopurinol Nsg

A

Alkaline-ash diet, no ETOH, increase fluids

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26
Q

Colchicine MOA/Tx

A

Anti-inflammatory for gout/Gout

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27
Q

Colchicine AE

A

Abd pain, N/V/D (common)

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28
Q

Colchicine Contra

A

Sever GI disorders, hepatic/renal impairment

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29
Q

Colchicine Nsg

A

*Alkaline-ash diet, take w/ food, avoid fish (purine)

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30
Q

Probenecid MOA/Tx

A

Increases uric acid excretion/Gout

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31
Q

Probenecid AE

A

GI rxn, renal injury

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32
Q

Probenecid Contra

A

*Do NOT use concurrently with salicylates (bleeding)

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33
Q

Probenecid Nsg

A

Take w/ food, increase fluids

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34
Q

Cyclosporine MOA/Tx

A

Inhibits T-lymphocytes (immunosuppressant)/Organ rejection

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35
Q

Cyclosporine AE

A

*Hirsutism, nephrotoxicity, infection

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36
Q

Cyclosporine Nsg

A

*Do not give w/ “azole” drugs (CYP-450), monitor for infection

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37
Q

Glucocorticoids in Immune Tx

A

Organ rejection

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38
Q

Glucocorticoids in Immune AE

A

Cushing’s disease, glucose intolerance, infection

39
Q

Glucocorticoids in Immune Nsg

A

Accumulate in body

40
Q

Azathioprine MOA/Tx

A

Inhibits B and T lymphocytes (immunosuppressant)/Adjunct to help suppress organ rejection

41
Q

Azathioprine AE

A

*Bone marrow suppression (causes thrombocytopenia and neutropenia)

42
Q

Azathioprine Nsg

A

Monitor PT/INR

43
Q

Mycophenolate MOA/Tx

A

Inhibits B and T cell proliferation/Organ rejection

44
Q

Mycophenolate AE

A

*Sepsis. GI rxns, neutropenia

45
Q

Mycophenolate Nsg

A

*Doses are blood level dependent and MUST be given on time

46
Q

Tacrolimus MOA/Tx

A

Inhibits T-lymphocyte activation/Organ rejection

47
Q

Tacrolimus AE

A

Nephrotoxic, GI rxns, infection

48
Q

Tacrolimus Nsg

A

Dosage is weight based according to organ transplanted

49
Q

Didanosine MOA/Tx

A

First line antiviral/HIV

50
Q

Didanosine AE

A

Lactic acidosis, hepatotoxic

51
Q

Didanosine Nsg

A
  • Take on empty stomach (30 min before or 2 hrs after meal)

* Only to tx HIV

52
Q

Efavirenz MOA/Tx

A

NNRTI/HIV

53
Q

Efavirenz AE

A

*Rash (adults 27% children 40%), CNS symptoms (~50% of pts will have this)

54
Q

Efavirenz Nsg

A

Do not skip doses, Monitor for rash (SJS)

55
Q

Zidovudine MOA/Tx

A

NRTI/HIV

56
Q

Zidovudine AE

A

*Bone marrow suppression, lactic acidosis, hepatomegaly

57
Q

Zidovudine Contra

A

Caution in liver disease and bone marrow suppression

58
Q

Zidovudine Nsg

A

Monitor all tests having to do with liver and blood

59
Q

Lopinavir/Ritonavir MOA/Tx

A

Protease inhibitor/HIV

60
Q

Lopinavir/Ritonavir AE

A

Hyperglycemia, osteoporosis, pseudo-cushings syndrome, N/V/D, HA

61
Q

Lopinavir/Ritonavir Contra

A

Breastfeeding

62
Q

Lopinavir/Ritonavir Nsg

A

Report s/s of DI, caution in liver disease, CYP-450

63
Q

Enfuvirtide MOA/Tx

A

Blocks entry into CD4 cells/HIV

64
Q

Enfuvirtide AE

A

*Injection site reaction, bacterial pneumonia

65
Q

Enfuvirtide Nsg

A

Sub-Q injection BID, rotate sites, monitor for bacterial pneumonia

66
Q

Doxorubicin MOA/Tx

A

Anthracycline/Antitumor abx(chemo)

67
Q

Doxorubicin AE

A

Red coloration to urine/sweat, acute cardiac toxicity, dysrhythmias, HF

68
Q

Doxorubicin Contra

A

Severe myelosuppression, and a lifetime cumulative dose of 550 mg/m^2, prego cat D

69
Q

Doxorubicin Nsg

A

Monitor ECG/cardiac fxn, f/u appt. to screen for delayed cardiac toxicity, pt should notify HCP of chest pain/SOB

70
Q

Carmustine MOA/Tx

A

Nitrosureas/Chemo

71
Q

Carmustine AE

A

Pulmonary fibrosis, liver and kidney toxicity

72
Q

Carmustine Contra

A

Severe myelosuppression, impaired pulmonary fxn, prego cat D

73
Q

Carmustine Nsg

A

Encourage fluids, monitor for bleeding/infection

74
Q

Cyclophosphamide MOA/Tx

A

Nitrogen Mustards/Chemo

75
Q

Cyclophosphamide AE

A

Bone marrow suppression, bleeding

76
Q

Cyclophophamide Contra

A

Sever myelosuppression, caution in w/ kidney/liver disorders

77
Q

Cyclophosphamide Nsg

A

Encourage fluids, monitor bleeding/infection

78
Q

Cisplatin MOA/Tx

A

Platinum compound/Chemo

79
Q

Cisplatin AE

A

*Hearing loss, renal toxicity

80
Q

Cisplatin Contra

A

Hearing loss, severe myelpsuppression, kidney disorders

81
Q

Cisplatin Nsg

A

*Monitor hearing prior to tx, encourage fluids, monitor bleeding/infection

82
Q

Interferon MOA/Tx

A

Biological response modifier/Chemo

83
Q

Interferon AE

A

Flu-like s/s, bone marrow suppression, depression

84
Q

Interferon Contra

A

Suicidal thoughts, colitis, pancreatitis, caution in liver/kidney/heart/lung disease/DM/depression

85
Q

Interferon Nsg

A

Store in refrigerator (Do not freeze) and admin at room temp, monitor: flu s/s, CBC, platelets, e-, and fluid status

86
Q

Leuprolide MOA/Tx

A

GRHA/Prostate CA

87
Q

Leuprolide AE

A

Hot flashes, decreased libido, gynecomastia, decreased bone density, arrhythmias, pulmonary edema

88
Q

Leuprolide Contra

A

Prego cat X

89
Q

Leuprolide Nsg

A

Increase Ca and Vit D intake, encourage weight-bearing exercise, prostate symptoms may worsen at beginning of Tx, Monitor: PSA, testosterone levels, arrhythmias, breath sounds

90
Q

Tamoxifen MOA/Tx

A

Hormonal agent/Breast CA

91
Q

Tamoxifen AE

A

Endometrial CA, HyperCa, N/V, pulmonary embolus, hot flashes, vaginal discharge/bleeding

92
Q

Tamoxifen Contra

A

Pt taking warfarin or w/ Hx of blood clots/pulmonary embolism, prego cat D

93
Q

Tamoxifen Nsg

A

Increase Ca and vit D intake, encourage weight-bearing exercise, preform monthly BSE and annual exams w/ provider, use birth control during therapy

Pharmacology 2 (5 decks)

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