Pharm 2 - Exam 3

Question 1

Other name for chemotherapeutic drugs

Answer 1

Antineoplastic drugs

Question 2

What do most conventional chemo drugs exert there affect?

Answer 2

on antineoplastic effects on cells that are actively divinding (mitosis) or undergoing DNA synthesis

Question 3

Many therapeutic drugs act only at _______

Answer 3

specific phases of the cell cycle

Question 4

What is often unresponsive or at best partially responsive to conventional chemo?

Answer 4

slow growing malignant cells w/ slow rate of division (carcinoma of the lung or colon)

Question 5

What cells are more vulnerable to toxic effects of chemo drugs?

Answer 5

rapidly dividing normal cells

Question 6

Examples of rapidly dividing cells

Answer 6

bone marrow
GI mucosa
skin
hair

Question 7

CLinical manifestations of toxicity to chemo:

Answer 7

n/v
myelospuression
diarrhea
mucosal ulcers
dermatitis
alopecia

Question 8

What is myelosupression?

Answer 8

leukopenia
thrombocytopenia
anemia

Question 9

What is the dose-limiting factor for many chemo drugs and is the most common toxicity that leads to temporary or permanent withdrawal of therapy?

Answer 9

myelosupression