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MSRA > Pharm > Flashcards

Pharm Flashcards

1
Q

Most common SE of Mg salts

A

Diarrhoea

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2
Q

Metformin with diarrhoea

A

If metformin is not tolerated due to GI side-effects, try a modified-release formulation before switching to a second-line agent

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3
Q

What drug precipitate azathiptine toxicity

A

Allopurinol

Causes BM failure

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4
Q

CCB SE

A

headache, flushing, ankle oedema

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5
Q

Beta blocker overdose

A

if bradycardic then atropine
in resistant cases glucagon may be used

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6
Q

SE of TB meds

A

Rifampicin
hepatitis, orange secretions

Isoniazid
peripheral neuropathy: prevent with pyridoxine (Vitamin B6)

Pyrazinamide
Gout
Hepatitis

Ethambutol
Optic neuritis

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7
Q

When should metformin be stopped

A

GFR <30
Recent MI, AKI, sepsis

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8
Q

Mx of OD of benzo

A

Flumazenil

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9
Q

Mx of OD of TCA

A

IV bicarb

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10
Q

Mx of heparin OD

A

Protamine sulphate

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11
Q

Mx of iron OD

A

Desferrioxamine

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12
Q

Mx of organophosphate OD

A

Atropine

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13
Q

Mx of methanol poisoning

A

fomepizole or ethanol
haemodialysis

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14
Q

Meds causing digoxin toxicity

A

Thiazides

Amiodarone, verapamil

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15
Q

How heparin is monitored

A

APTT

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16
Q

Effect on baby if on lithium

A

Ebstein

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17
Q

Monitoring bloods on statin, ace, amiodarone, methotraxate, azathioprine, lithium, valproate, glitazones

A

Statin-lft
Amiodarone- Tft, lft
Meth- fbc, let, u+e
Aza- fbc, lft, U+e
Lithium- lithium, tft,u+e
Valproate- lft
GLitazone- lft

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18
Q

Meds CI in HF

A

thiazolidinediones
pioglitazone is contraindicated as it causes fluid retention
verapamil
negative inotropic effect
NSAIDs/glucocorticoids

19
Q

Amiodarone SE

A

Thyroid
Pul fibrosis
Liver fibrosis
Neuropathy
Photosensitive
Brady
Long QT

20
Q

St John’s Wort P450

A

Inducer

21
Q

Tamoxifen SE

A

menstrual disturbance: vaginal bleeding, amenorrhoea
hot flushes - 3% of patients stop taking tamoxifen due to climacteric side-effects
venous thromboembolism
endometrial cancer

22
Q

Medications held in AKI

A

ACEi ARB
Metformin
Diuretics
NSAIDs

23
Q

Inducers of P450

A

Pheny
Carbmazepine
Rifampicin
St Johns Wort

24
Q

HRT prescription

A

Perimenopause (less than 12 months)- cyclical

continuous combined HRT if they have:
taken cyclical combined for at least 1 year or
it has been at least 1 year since their LMP or
it has been at least 2 years since their LMP, if they had premature menopause

Transdermal to reduce VTE

25
Q

Aspirin MOA

A

non reversible COX 1 and 2 inhibitor

26
Q

Drug induced photosensitivity

A

thiazides
tetracyclines, sulphonamides, ciprofloxacin
amiodarone

27
Q

Break through analgesia prescription

A

1/6th total dose

28
Q

CI to sildenafil

A

Recent stroke or MI

29
Q

SE of diabetic meds

A

Metformin- GI
Sulfonylurea- hypoglycaemia
Glitazone- weight gain
GLiptins- pancreatitis

30
Q

Drug induced thrombocytopenia

A

Quinine
Penicillin
Carbamazepine

31
Q

Ix before starting on trastuzumab

A

Trastuzumab

32
Q

Salicylate OD

A

hyperventilation (centrally stimulates respiration)
tinnitus
lethargy
sweating, pyrexia*

33
Q

Visual changes secondary to drugs

A

blue vision: Viagra (‘the blue pill’)
yellow-green vision: digoxin

34
Q

Liver transplant after paracetamol OD criteria

A

Arterial pH < 7.3, 24 hours after ingestion

or all of the following:
prothrombin time > 100 seconds
creatinine > 300 µmol/l
grade III or IV encephalopathy

35
Q

What should be prescribed with isoniazid

A

pyridoxine

36
Q

Quinilone SE

A

Lower seizure threshold
Tendon damage
Lengthen QT

37
Q

What can precipitate lithium toxicity

A

dehydration
renal failure
drugs: diuretics (especially thiazides), ACE inhibitors/angiotensin II receptor blockers, NSAIDs and metronidazole.

38
Q

Drugs causing ocular problems

A

Cataracts
steroids

Corneal opacities
amiodarone
indomethacin

Optic neuritis
ethambutol
amiodarone
metronidazole

Retinopathy
chloroquine, quinine

39
Q

Antiplatelets before dental procedure

A

Take as normal

40
Q

When is nitro CI

A

CKD 3

41
Q

Tx of antifreeze poisoning

A

Fomepizole

42
Q

When are paracetamol levels measured after ingestion

A

4 hours

43
Q

Azathioprine in pregnancy

A

Safe to use

MSRA (10 decks)

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