Pharm Flashcards
Most common SE of Mg salts
Diarrhoea
Metformin with diarrhoea
If metformin is not tolerated due to GI side-effects, try a modified-release formulation before switching to a second-line agent
What drug precipitate azathiptine toxicity
Allopurinol
Causes BM failure
CCB SE
headache, flushing, ankle oedema
Beta blocker overdose
if bradycardic then atropine
in resistant cases glucagon may be used
SE of TB meds
Rifampicin
hepatitis, orange secretions
Isoniazid
peripheral neuropathy: prevent with pyridoxine (Vitamin B6)
Pyrazinamide
Gout
Hepatitis
Ethambutol
Optic neuritis
When should metformin be stopped
GFR <30
Recent MI, AKI, sepsis
Mx of OD of benzo
Flumazenil
Mx of OD of TCA
IV bicarb
Mx of heparin OD
Protamine sulphate
Mx of iron OD
Desferrioxamine
Mx of organophosphate OD
Atropine
Mx of methanol poisoning
fomepizole or ethanol
haemodialysis
Meds causing digoxin toxicity
Thiazides
Amiodarone, verapamil
How heparin is monitored
APTT
Effect on baby if on lithium
Ebstein
Monitoring bloods on statin, ace, amiodarone, methotraxate, azathioprine, lithium, valproate, glitazones
Statin-lft
Amiodarone- Tft, lft
Meth- fbc, let, u+e
Aza- fbc, lft, U+e
Lithium- lithium, tft,u+e
Valproate- lft
GLitazone- lft
Meds CI in HF
thiazolidinediones
pioglitazone is contraindicated as it causes fluid retention
verapamil
negative inotropic effect
NSAIDs/glucocorticoids
Amiodarone SE
Thyroid
Pul fibrosis
Liver fibrosis
Neuropathy
Photosensitive
Brady
Long QT
St John’s Wort P450
Inducer
Tamoxifen SE
menstrual disturbance: vaginal bleeding, amenorrhoea
hot flushes - 3% of patients stop taking tamoxifen due to climacteric side-effects
venous thromboembolism
endometrial cancer
Medications held in AKI
ACEi ARB
Metformin
Diuretics
NSAIDs
Inducers of P450
Pheny
Carbmazepine
Rifampicin
St Johns Wort
HRT prescription
Perimenopause (less than 12 months)- cyclical
continuous combined HRT if they have:
taken cyclical combined for at least 1 year or
it has been at least 1 year since their LMP or
it has been at least 2 years since their LMP, if they had premature menopause
Transdermal to reduce VTE
