pharm

Question 1

Define pharmacodynamics

Answer 1

biological and physiological effects of drugs and their mechanisms of action

Question 2

Pharmacokinetics?

Answer 2

How drug moves thru body to sites of action

Question 3

define absorption

Answer 3

how drug gets into blood, rate/ extent it leaves site of admin

Question 4

bioavailability is _____, and determines ______

Answer 4

how much of a drug dose gets to the site of action, determines effect

Question 5

Drug dose is calculated by______

Answer 5

weight (mg/kg)

Question 6

Route of administration determines _______

Answer 6

bioavailability

Question 7

Sublingual administration avoids_____

Answer 7

first pass metabolism

Question 8

first pass metabolism

Answer 8

drugs absorbed into GI tract are filtered thru liver before site of action

Question 9

drugs must be ____ soluble to pass the ______ barrier

Answer 9

lipid,, blood brain barrier

Question 10

elimination occurs by ______ and ______

Answer 10

direct excretion, metabolism

liver and kidneys impo

Question 11

Effective dose (EDx)is ?

Answer 11

Dose at which x% of users show certain effect

Question 12

Lethal dose (LDx) is?

Answer 12

dose at which x% of users die

Question 13

Dose effect curve , ____________ is on X axis, _______ is on Y axis

Answer 13

Dose size, response size

Question 14

effiacy vs potency

Answer 14

effiacy - most intense peak of drug effect
potency -minimum effective dose

drug a and b have same effect but a produces same effect at lower dose , a is more potent.

Drug A and C produce effect at same dose but C has a higher peak- they are equally potent but C is more effective.

Question 15

Drug antagonism is ?

Answer 15

Reduced effect when another drug is present

Question 16

Potentiation is ?

Answer 16

drugs enhancing effects of each other