jazz cabbage Flashcards
explain how THC impacts the reward circuit when dopamine neurons do not have CB1 receptors
When THC binds to cb1 receptors on GABA neurons, GABA is prevented from inhibition of Dopamine, resulting in an increase of dopamine in the Reward Circuit
What is common factor theory
Propensity to use drugs and exposure to hard drugs are more likely the cause of hard drug use. People do often use marijuana first, but it does not CAUSE hard drug use
Why does time pass slow when using marijuana
high density of CB1 receptors in areas of brain involved in memory, memory helps judge passing of time
what NT binds to same receptors on brain cells as do cannabinoids
Anandamide
what medical applications does marijuana have
appetite increase for aids and cancer patients
nasuea mangament
pain mgmt
most rapid and efficient absorption of marijuana
Inhalation/smoking- results in 10-27% bioavailability
most thc is burned away
What effect does MJ have on immune system
suppressant
cb2 receptors immunosuppressive when stimulated- gives anti inflammatory properties
THC is used to treat glaucoma by
reducing intraocular pressure
but is not effective in long term as tolerance develops to this effect
What is puff topography
Efficient inhalation leads more thc to sites of action, experienced smokers more able to maximise thc into bloodstream
primary psychoactive agent in mj
THC
where does thc bind in the brain
CB1 receptors are present in basal ganglia, cerebellum, hippocampus , prefrontal cortex
