pH Flashcards
1
Q
What is Type 1 Diabetes
A
Autoimmune disease. Body attacks the beta cells in the pancreas and kills them so no insulin can be produced.
2
Q
What is Type 2 Diabetes
A
Body has difficulty producing insulin based on pathways. Think Randal’s class.
3
Q
What does an increase in glucose do?
A
Release fatty acids
4
Q
What do fatty acids produce? What’s its pKa?
A
Ketones and their pH is lower than physiological pH of 7.4
5
Q
Do enzymes require a specific pH?
A
Yes
6
Q
Name 3 enzyme examples for pH
A
- Pepsin in the stomach (pH of 2ish)
- Trypsin in the duodenum (pH of 6ish)
- Alkaline Phosphatase in the mitochondria (pH of 8-9ish)
7
Q
What are 3 ways pH can change an enzyme?
A
- Loss of activity
- Loss of solubility
- Loss of shape
8
Q
Does the blood in the lungs or tissues have a higher pH
A
Lungs
9
Q
Is Hgb more saturated at lower or higher pH’s?
A
Higher
10
Q
Nucleus pH
A
7.2
11
Q
ER pH
A
7.0
12
Q
Golgi (cis) pH
A
6.7
13
Q
Golgi (medial) pH
A
6.3
14
Q
Golgi (trans) pH
A
6.0
15
Q
Mitochondria pH
A
8.0
