PFK-1 Regulation In Muscle

Question 1

PFK-1 Stimulation

Answer 1

By AMP:
Contracting muscle/energy deficient —> increase AMP —> increase PFK-1 —> increase Fructose 2,6 BisP —> increase blood glucose

Question 2

PFK-1 Inhibition

Answer 2

By ATP:

Resting muscle/energy excess —> increase ATP —> decrease PDK-1 —> decrease Fructose 2,6 BisP —> decrease blood glucose