Fructose 2, 6 BisP Regulation

Question 1

Insulin

Answer 1

• High blood glucose, low cAMP & PKA
• Dephosphorylation of Bifunctional Enzyme (PFK-2/FBP-2)
• Activate PFK-2, Inactive FBP-2
• Increase [Fructose 2, 6 BisP]
• Allosteric activation of PFK-1
• Increased rate of Glycolysis

Question 2

Glucagon

Answer 2

• Low blood glucose, high cAMP & PKA
• Phosphorylation of Bifunctional Enzyme (PFK-2/FBP-2)
• Active FBP-2, Inactive PFK-2
• Decrease [Fructose 2, 6 BisP]
• Activation of Fructose 1, 6 BiPase
• Increase rate of Gluconeogenesis