Persons Flashcards
Practical experience and theory in pcol
Claudius galen
Rational use of drugs
Claudius galen
Active ingredients in prescribed medicine
Theophrastus von hohenheim
Poisoner
Theophrastus von hohenheim
All subs are poison except for the right dose
Theophrastus von hohenheim
Animal experiments about pcol and toxi
Johann jakob wepfer
First institution of pharmacology
Rudolf buchheim, at univ of dorpat (estonia)
Chemical properties of drugs
Rudolf buchheim
Father of modern pcol
Oswald schmiedeberg
1st journal pcol
Archiv for experimental pathology and pharmacology
1st journal pcol who
Oswald schmiedeberg, bernhard naunyn, edwin klebs
SAR
Thomas richard frazer
Drug receptor
J. Langley
Selective toxicity
Paul ehrlich
First formalized receptor theory
Alexander j. Clark
Apply law of mass action to drug-receptor interactions
Alexander j. Clark
Father of modern american pharmacology
John j. Abel
Founder of journal or pharmacology and experimental therapeutics
John j. Abel
Theoretical background of pcol
Claudius galen
theory: pcol effect depends on the percentage of receptors occupied, affinity
Hypothesis of clark
Theory: occupational, effectivenes lasts as long as the receptor is occupied, affinity and intrinsic activity
Theory of ariëns and stephenson
Theory: rate, effectivenes does not depend upon actual occupation of the recotor but upon obtaining the proper stimulus only
Hypothesis of paton
Theory: drug molecule must fit into the receptor
Lock and key theory
