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Autacoids Flashcards

1
Q

Ions link to histamine release

A

Calcium

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2
Q

Physiologic antagonist during histamine release

A

Epinephrine

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3
Q

Tx for histamine release

A

Epinephrine, mast cell stabilizers, bronchodilators

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4
Q

Mast cells stabilizers

A 
Chromolym sodium (nasalchrom) 
Nedrocromil sodium (tilade)
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5
Q

1st gen H1 overdose

A

Atropine like effects

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6
Q

2nd gen H2 overdose

A

Cardiac arrhythmias

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7
Q

DI for antihistamines H1

A

Drugs that inhibit cyp3A4 (antimicrobials)

Cns depressants

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8
Q

1st generation drugs

A 
Ethanolamines
Ethylenediamines
Piperazine
Alkylamines
Phenothiazine
Dibenzoclycoheptenes
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9
Q

2nd generation H1 antihistamines

A

Piperidines
Cetirizine
Acrivastine

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10
Q

Ethanolamines drugs

A

Carbinoxamine
Dimenhydrinate
Diphenhydramine
Doxylamine

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11
Q

Ethylenediamine drugs

A

Pyrilamine

Tripelennamine

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12
Q

Piperazine drugs

A

Hydroxyzine
Cyclizine
Meclizine

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13
Q

Alkylamine drugs

A

Brompheniramine

Chlorpheniramine

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14
Q

Phenothiazine drugs

A

Promethazine

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15
Q

Dibenzocycloheptenes

A

Cryoheptadine

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16
Q

Piperidines

A

Astemizole
Fexofenadine
Terfenadine
Loratadine

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17
Q

H1 antihist with serotonin blocking action

A

Cyproheptadine

18
Q

H1 antihist with possible teratogenic effects

A

Piperazine drugs (hydroxyzine, cyclizine, meclizine)

19
Q

H2 blocker with most side effect

A

Cimetidine

20
Q

H2 antagonist safest

A

Famotidine

21
Q

H2 blocker that binds to androgen receptors, effects?

A

Cimetidine, gynecomastia, galactorrhea

22
Q

Effects of 5ht1

A

Vasoconstriction, behavioral actions increase happiness

23
Q

Effects of 5ht2

A

Vasoconstriction

24
Q

Effects of 5ht3

A

Vasoconstriction, anti-emetic, antidiarrheals

25
Q

Effects of 5ht4

A

Anticonstipation

26
Q

5ht1a agonists

27
Q

5ht2 agonist

A

Ergot alkaloids (ergotamine, lysergic acid diethylamide)

28
Q

5ht3 agonist

29
Q

5ht4 agonist

A

Cisapride, tegaserod

30
Q

5ht3 antagonist

A

Ondansetron, granisetron, dolasetron, cyproheptadine

31
Q

5ht2 antagonist

A

Ketanserin, ritanserin

32
Q

PGE1 analogs

A

Alprostadil, misoprostol

33
Q

PGE2 analogs

A

Dinoprostone

34
Q

PGF2a analogs

A

Carboprost
Dinoprost tromethamine
Latanoprost

35
Q

PGI2 analog

A

Prostacyclin

36
Q

Inhibits phospholipase A2

A

Glucocorticoids

37
Q

Inhibitors of cox

38
Q

Inhibits lipoxygenase

39
Q

Leukotriene antagonist

A

Montelukast, zafirlukast,

40
Q

Effects of leukotrienes

A

Bronchoconstriction. Edema. Increase mucus. Increase bronchial activity.

41
Q

Triple response skin due to histamine

A 
Reddening (local vasodilation)
Wheal formation (capillary permeability)
Flare formation (irritation of sensory nerve endings)

Pharmacology (12 decks)

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