Parkinson's Disease Flashcards
Other term for parkinsonism
Paralysis agitans, shaking palsy
Cardinal signs of parkinsons
TRAP Tremor at rest Rigidity Akinesia or bradykinesia Postural instability
Drugs that induces parkinsonism
Antipsychotics
Anit-emetics
Reserpine
Drugs that reduces parkinsonism
Dopamine precursor Dopamine agonist COMT inhibitors MAOB inhibitors Antimuscarinic drugs Amantadine
Rhythmic oscillatory movement around a joint
Tremors
Types of tremors
Resting tremors
Postural tremors
Intention tremors
Irregular, unpredictable, involuntary muscle jerks that occurs in different parts of the body and impair voluntary activity
Chorea
Sudden coordinated abnormal movement that occurs repetitively
Tics
Abnormal movements that are slow and writhing in character
Athetosis
Characterized by a variety of abnormal bizarre movement
Tardive dyskinesia
Most common complication of long term anti psychotic treatment
Tardive dyskinesia
Sustained abnormal movements cause by involuntary contraction of muscles
Dystonia
I-isomer of dopa
Levodopa
Natural precursor of all catecholamines
DOPA
T/F L- dopa can cross BBB while dopamine can’t
T
Combination dose give in combined levodopa and carbidopa
Ratio 1:4 (25/100mg) or 1:10 (10/100mg)
Ethyl ester pro drug of levodopa
Etilevodopa
T/F GI side effect is less common for combined levodopa and carbidopa
T
Adjunct tx for carbidopa/levodopa theraphy
Dopamine agonist
Peripheral dopa decarboxylase inhibitor
Carbidopa
It helps increases the bioavailability of levodopa
Carbidopa
Metaboliteof selegiline
Desmethyl-selegiline
Used in patients experiencing wearing off phenomenon
Selegiline
Orally disintegrating tablet, freeze dried absorbed through oral mucosa
Zydis selegiline
Vascular cutaneous reaction charc by reddish purple fishnet-patterned mottling of the upper and lower extremities
Amantadine
Subcutaneous injection effective for temporary relieving offline eriod of akinesia patients on optimized dopamine theraphy
Apomorphine
Slow progressive degenerative neurologic disorder of muscle movement
Parkinsonism
Antiviral agent used for prophylaxis and tx of imfluenza
Amantadine
Also acailble in liquid preparation for patients with dysphagia
Amantadine
