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Pharmacology > Antipsychosis > Flashcards

Antipsychosis Flashcards

1
Q

Effects of low in dopamine

A

EPS

Weight gain

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2
Q

Major tranquilizers or neuroleptic drugs

A

Antipsychotic drugs

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3
Q

Class of antipsychotics that blocks d2 receptor only

A

Traditional

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4
Q

Class of antipsychotic drugs that blockes d2 and serotonin receptors

A

Non traditional

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5
Q

Arrange potency of antipsychotics

A

Butyrophenones = piperazine derivatives > piperidine > thioxanthenes&raquo_space; aliphatics

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6
Q

About equally potent in d2 and serotonin blocking

A

Risperidone

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7
Q

Active metabolite of risperidone

A

Paliperidone

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8
Q

More potent as an antagonist of serotonin

A

Olanzapine

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9
Q

Partial agonist effect at d2 and 5ht1a receptors

A

Aripiprazole

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10
Q

Adverse effect of alpha adrenergic block

A

Orthostatic hypotention, failure to ejaculate, i potence

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11
Q

Dopamine receptor block

A

Extrapyramidal effects

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12
Q

Extrapyramidal side effects

A

Akathisia (uncontrolled restless ness)
Acute dystonia (spastic retrocollis/torticollis)
Parkinson’s syndrome

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13
Q

Dopamine receptor hypersensitivity

A

Tardive dyskinesia (abnormal choreoathetoid movements)

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14
Q

Prototype atypucal antipsychotic drug

A

Clozapine

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15
Q

The only atypical agent that is EPS free and TD (tardive dyskinesia free)

A

Clozapine

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16
Q

Reserved as last line due to risk of fatal and need for frequent laboratory testing

A

Clozapine

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17
Q

Long acting, depot antipsychotics (IM)

A

Fluphenazine, haloperidol decanoate

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18
Q

Theraphy for non compliant antipsychosis

A

Give long acting, depot antipsychosis if NR
Give clozapine if NR
Give addition of mood stab

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19
Q

Proven effective for refractory patients (antipsychotic)

A

Clozapine

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20
Q

Augmentation therapy of antipsychosis

A

Addition of mood stabilizing agents

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21
Q

General adverse effects of antipsychotics

A

Alpha adrenergic block
Dopaminergic block
Muscarinic block

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22
Q

Uncontrolled restlessness

A

Akathisia

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23
Q

Spastic retrocollis/ torticollis

A

Acute dystonia

24
Q

Abnormal choreoathetoid movement

A

Tardive dyskinesia

25
Q

AE seizures

26
Q

AE agranulocytosis

27
Q

AE cardiotoxicity

A

Thioridazine, ziprasidone, clozapine

28
Q

AE Qt prolongation

A

Thioridazine, thioziprasidone

29
Q

AE myocarditis

30
Q

AE corneal deposit

A

Clorpromazine

31
Q

Lens deposit

A

Chlorpromazine

32
Q

AE retnal deposit

A

Thioridazine

33
Q

AE browning of the vision

A

Thioridazine

34
Q

Increase risk of DM

A

Olanzapine

35
Q

For tx of + symptoms

A

Typical and atypical antipsychosis

36
Q

For tx of - sympt

37
Q

Neuroleptanesthesia

A

Droperidol + fentanyl

38
Q

Common complication due to long term use of antipsychotics

A

Tardive dyskinesia

39
Q

Restless leg syndrome

40
Q

Abnormal movement of any body part (face, tongue, shoulders, hips, extremities)

A

Tardive dyskinesia

41
Q

Pill rolling with fingers, limb rigidity, shuffling gait, bradykinesia

A

Pseudo parkinsonism

42
Q

Sudden muscular spasm of the face, neck back eyes and tongue

A

Acute dystonia

43
Q

Neck twisted to the side

A

Torticollis

44
Q

Neck pulled back

A

Retrocollis

45
Q

Clenched jaw

46
Q

Fixed upward gaze

A

Oculogyric crisis

47
Q

Rare, idiosyncrathic reaction caused by dopamine blockage

A

Neuroleptic malignant syndrome

48
Q

T/F traditional agents block dopamine receptors, whereas non trad block serotonin receptors to a higher degree

49
Q

T/F non trad have less EPS than the traditional agents

50
Q

T/F non trad tx negative symptoms better than trad

51
Q

T/F high potency antipsychotics are favored due to lesser adverse effects

52
Q

T/F dopamine inhibits prolactin release

53
Q

T/F low potency agents are more likely to cause EPS

54
Q

T/F high potency agents more commonly produce anticholinergic effects, sedstion, and cardio side effects

55
Q

Effects of high in dopamine

A

Psychosis
Inhibits prolactin secretion
Decreased apetite

Pharmacology (12 decks)

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