peripheral vasodilator2

Question 1

how do vasodilators work?

Answer 1

lead to nitric oxide with afects guanylate cyclase leads to increased cGmp—> decreased ca release from SR which leads to decreased calcium and decreased contraction

Question 2

venous dilation leads to

Answer 2

decreased venous return, decreased cardiac output

Question 3

arterial dilation leads to

Answer 3

decreased systemic vascular resistance (SVR)

Question 4

what 3 meds lead to nitric oxide

Answer 4

nitroglycerin, nipride, adenosine

Question 5

NO is released

Answer 5

at site of action

Question 6

how does release of tourniquet cause vasodilation

Answer 6

cell mediators (ACH, histamine, bradykinin, atp lead to nitric oxide which leads to vasodilation

Question 7

abrupt d/c of nipride leads to

Answer 7

rebound hypertension

Question 8

nipride causes

Answer 8

decrease preload, decrease afterload, increase stroke volume, decrease pulm vascular resistance (Mostly arterial dilation)

Question 9

nipride may cause

Answer 9

coronary steal due to arterial dilation shunting blood away from fixed lesion

Question 10

is there direct myocardial depression with nipride

Answer 10

no

Question 11

all vasodilators can cause

Answer 11

reflex tachycardia

Question 12

nitroglycerin primarily affects

Answer 12

preload (venous)

Question 13

nitroglycerin action

Answer 13

some artery, mostly venous, increase pooling, decreased filling pressure, decreased myocardial o2 demand, increased endocardial perfusion

Question 14

how does nitroglycerin help with ischemia

Answer 14

decrease stretch secondary to decreased preload causes decreased compression of coronary arteries and increased coronary perfusion.

Question 15

does nitroglycerin have coronary steal

Answer 15

no

Question 16

hydralazine mech action

Answer 16

unknown, k channel though tot be mech

Question 17

hydralazine leads to

Answer 17

decreased BP, tachycardia

Question 18

adenosine causes

Answer 18

coronary steal