ccb 2

Question 1

calcium is important in

Answer 1

contraction of vascular smooth muscles, skeletal muscle and heart muscle

Question 2

blocking ca channels causes

Answer 2

decrease influx into cell, decreased action

Question 3

ca and myocytes

Answer 3

ca binds to troponin, links to crossbridging and pulls filaments which equals contraction

Question 4

smooth muscle and calcium

Answer 4

binds to camodulin causing actin and myosin interaction- both require by g protein and ac activation and camp/ip3 activity

Question 5

increased ca in cell from

Answer 5

increased influx and increased release from SR

Question 6

camp acts as an

Answer 6

2nd messenger- increased CAMP causes an increase in intracellular calcium

Question 7

what breaks down camp

Answer 7

phosphodiestarase

Question 8

phosphodiesterase inhibitor does what

Answer 8

increases intracellular calcium and increases contraction

Question 9

more phosphodiesterase

Answer 9

more breakdown camp

Question 10

how is calcium activated and exert effect

Answer 10

excitation coupling

Question 11

which ccb suppresses AV node the most

Answer 11

verapamil

Question 12

what does verapamil do to heart rate

Answer 12

marked decrease

Question 13

what ccb decreases heart rate second most

Answer 13

diltiazem

Question 14

which ccb have no decrease in hr

Answer 14

dihydrapyradines- DHP- nifedipine, nicardipine, clevidipine

Question 15

what does niffedipine do to HR

Answer 15

marked increase secondary to baroreceptor

Question 16

NON DHP effects

Answer 16

negative inotropic (decrease contractility)
negative chronotropic (decrease HR)
negative dromotropy (decrease conduction
negative lusitropy(relax heart)

Question 17

what is the difference between nodal and myocyte action potential

Answer 17

nodal have automaticity, dont need stimulation like myocytes do on own

Question 18

where does automaticity occur on nodal tissue

Answer 18

phase 4- mostly ca entering cell, some na

Question 19

what would happen in phase 4 if block calcium channel into cell

Answer 19

decrease action potential, decrease HR

Question 20

what phase of nodal tissue does ccb cause negative chronotropic effect

Answer 20

4

Question 21

what phase does ccb cause negative inotropic effects

Answer 21

phase 2 on myocyte cell- not on nodal cell

Question 22

ccb do what to coronary arteries?

Answer 22

dilate

Question 23

what can ccb cause

Answer 23

coronary steal

Question 24

why is cardizem better then nifedipine for ischemic patient

Answer 24

decrease HR, increase filling time gives more time for coronary perfusion

Question 25

do you use DHP for angina?

Answer 25

typically not

Question 26

shortest acting CCB

Answer 26

clevidipine

Question 27

greatest effect contractility, chronotropic, dromotropic, inotropic

Answer 27

verapamil