nsaids

Question 1

cox 1 is found

Answer 1

in all normal tissue- produces prostaglandins that are protective to gastric mucosa- pgi2, pge2

Question 2

cox 2 is found

Answer 2

at site of inflammation, not normal

Question 3

nsaids do what

Answer 3

inhibit cox2 (pain, inflammation, fever), but give unwanted cox1 results (gi ulceration)

Question 4

arachoidonic acid comes from where

Answer 4

cell membrane, cleaved off by phopholipase a2

Question 5

2 pathways arachoidonic acid can taeke

Answer 5

lipogenase or cyclogenase

Question 6

lox pathway

Answer 6

arachoidonic acid is turned into leukotrienes by lipogenase

Question 7

product of lox pathway

Answer 7

lta4–>ltb4—>ltc4—>ltd4. these bind to leukotriene receptor and cause bronchoconstriction

Question 8

cox pathway

Answer 8

arachidonic acid is converted to prostaglandin h2 by cyclogenase (COX)

Question 9

3 products of prostaglandin H2

Answer 9

in platelet creates thromboxane A2 which is bad for the heart
2. in the endothelium makes prostacyclin (PGI2) which is good for the heart
3. turns into prostaglandins which are good or bad-
pge2 and pgf2 are good for the stomach (protective) COX1
pgd2 causes inflammation, fever and pain (COX2)