Peripheral Polyneuropathy

Question 1

3 categories of inherited polyneuropathies

Answer 1

Hereditary Motor and Sensory Neuropathy
Hereditary Sensory and Autonomic Neuropathy
Hereditary Motor Neuropathy

Question 2

Most commonly inherited polyneuropathy

Answer 2

Hereditary motor and sensory neuropathy, AKA Charcot-Marie Tooth Disease

Question 3

Recurrent short term episodes of motor and sensory mononeuropathies due to nerves being sensitive to pressure

Answer 3

Hereditary neuropathy with liability to pressure palsy (HNPP)

Question 4

HMSN is similar to what else in terms of same gene mutation

Answer 4

HNPP (hereditary neuropathy with liability to pressure palsy)

Question 5

Sensory loss along with thermal day’s regulation, bladder dysfunction and cognitive deficits

Answer 5

Hereditary sensory and autonomic neuropathy

Question 6

Progressive weakness and atrophy of UE and LE

Answer 6

Hereditary motor neuropathy

Question 7

Most common acquired polyneuropathy

Answer 7

Diabetes mellitus

Question 8

Typical distribution of symptoms of acquired polyneuropathy

Answer 8

Symptoms are distal and progresses proximally

Question 9

Multifocal motor neuropathy
Demyelination vs. axonal
Motor vs. sensory

Answer 9

Demyelinating

Motor

Question 10

HMSN I, II, III, IV
Demyelination vs. axonal
Motor vs. sensory

Answer 10

I, III, IV = demyelinating, sensorimotor

II = axonal, motor > sensory

Question 11

AIDP and CIDP
Demyelination vs. axonal
Motor vs. sensory

Answer 11

AIDP = Demyelinating or axonal, motor > sensory
CIDP = demyelinating, motor > sensory

Question 12

Diabetic neuropathy
Demyelination vs. axonal
Motor vs. sensory

Answer 12

Demyelination and axonal loss

Sensorimotor

Question 13

Lead toxicity
Demyelination vs. axonal
Motor vs. sensory

Answer 13

Axonal loss

Motor > sensory

Question 14

B12 deficiency
Demyelination vs. axonal
Motor vs. sensory

Answer 14

Axonal loss

Sensorimotor

Question 15

Friedrich’s ataxia
Demyelination vs. axonal
Motor vs. sensory

Answer 15

Axonal

Sensory

Question 16

Gold toxicity
Demyelination vs. axonal
Motor vs. sensory

Answer 16

Axonal loss

Sensorimotor

Question 17

Classic triad of polyneuropathies

Answer 17

1. Stocking/glove distribution
2. Distal weakness
3. Diminished/absent MSR

Question 18

Demyelinating vs axonal injury NCS:
Latency
CV
Amplitude
Temporal dispersion

Answer 18

Demyelinating = prolonged latency, decreased CV, Nml amplitude, increased temporal dispersion
Axonal = normal latency, normal CV, decrease amplitude, no temporal dispersion

Question 19

Demyelinating vs axonal injury EMG:
Fibrillations/PSWs
Myokymic discharges
Recruitment
Phases

Answer 19

Demyelinating = no fibs/PSWS, + myokymic discharges, decreased recruitment, normal phases.
Axonal = + fibs/PSWs, no myokymic discharges, decreased recruitment, polyphasic

Question 20

Hereditary vs acquired NCS:
Conduction block
CV
Temporal Dispersion

Answer 20

Hereditary = no conduction block, diffuse slowing CV, no dispersion.
Acquired = + Conduction block, focal slowing CV, increased dispersion.