peripheral nerve disease

Question 1

describe features of mono neuritis multiplex

Answer 1

multiple non-contiguous nerves
vasculitic or inflammatory
asymmetric weakness/sensory loss
distal > proximal weakness
usually painful

Question 2

name several systemic diseases associated with mono neuritis multiplex

Answer 2

polyarteritis nodosa
Wegeners granulomatosis
rheumatoid arthritis
leprosy
diabetes
lupus
sarcoidosis
lyme disease

Question 3

what are the 2 categories of polyneuropathies

Answer 3

axonal

demyelinating

Question 4

what are the diseases associated with demyelinating polyneuropathies

Answer 4

Guillon Barre (AIDP)
Chronic inflammatory demyelinating polyneuropathy (CIDP)
Charcot Marie tooth 1a
NCV findings: reduced conduction velocities, prolonged latency

Question 5

What are the diseases associated with Axonal polyneuropathies

Answer 5

Toxic, metabolic nutritional

NCV findings: reduced amplitude

Question 6

Describe the important features of Guillain Barre

Answer 6

• rapid onset symmetric weakness
• monophasic and preipheral
• respiratory failure major risk
• ascending weakness
• paresthesias
• areflexia
• facial weakness
• autonomic symptoms
• associated with CMV, EBV, HIV, immunizations, surgery
• albumin cytologic dissociation

Question 7

describe the important features of B12 deficiency polyneuropathy

Answer 7

degeneration of dorsal columns and spinal tract
loss of vibration/proprioception
large fiber nerve axonopathy
-paresthesias and stocking glove sensory loss

Question 8

name the nutritional polyneuropathies

Answer 8

B12
pyroxine
niacin
thiamine
alcohol
copper

Question 9

name the toxic polyneuropathies

Answer 9

chemotherapeutic agents (cisplatinum, vincristine, taxol)
isoniazid
organophosphates
heavy metals
alcohol

Question 10

what are the important features of Charcot Marie Tooth

Answer 10

Demyelinating (Slow NCV)
autosomal dominant
duplication of PMP22
pes cavus
hammer toe
hypertrophy of peripheral nerves