antidepressants Flashcards
Imiprazine
Class: TCA (tertiary amine)
Mechanism: NE/5-HT uptake
Side Effects: arrhythmias, av block, orthostatic hypotension
Desipramine
Class: TCA (secondary amine)
Mechanism: NE uptake
Side Effects: arrhythmias, av block, orthostatic intolerance
Fluoxetine
Class: SSRI
Mechanism: 5-HT uptake
Side Effects: Nausea, vomiting, sexual dysfunction, asthenia
venlafaxine
Class: SNRI
Mechanism: low dose NE uptake, high dose NE/5HT uptake
Side Effects: nausea vomiting, sexual dysfunction, asthenia
Phenelzine
Class: MAOI
Mechanism: irreversible MAO inhibition
Side Effects: hepatotoxicity, CNS, orthostatic hypotension, Cheese Rxn hypertensive crisis (tyramine)
Mirtazapine
Class: not classified
Mechanism: alpha-2 adrenoceptor blockade
Side Effects: weight gain