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Prudent Use of AB > Peptide ABs, Sulphonamides, Diaminopyrimidines, FQs etc. > Flashcards

Peptide ABs, Sulphonamides, Diaminopyrimidines, FQs etc. Flashcards

1
Q

What is the mode of action of Polypeptide ABs?

A

Concentration-dependent bactericidal

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2
Q

What is the mechanism of action of Polypeptide ABs?

A

Act like cationic detergent

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3
Q

What is the mode of action of Glycopeptide ABs?

A

Time-dependent bactericidal

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4
Q

What is the mechanism of action of Glycopeptide ABs?

A

Inhibition of cell wall synthesis

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5
Q

What is the mode of action of Rifamycins?

A

Time-dependent bactericidal

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6
Q

What is the mechanism of action of Rifamycins?

A

Inhibit bacterial DNA-dependent RNA polymerase

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7
Q

What is the mode of action of Pseudomonic acid?

A

Bactericidal

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8
Q

What is the mechanism of action of Pseudomonic acid?

A

Inhibition of cell wall synthesis

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9
Q

What is the mode of action of Phosphonic acid derivatives?

A

Bactericidal

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10
Q

What is the mechanism of action of Phosphonic acid derivatives?

A

Inhibition of cell wall synthesis

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11
Q

What is the mode of action of Fusidic acid?

A

Bacteriostatic

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12
Q

What is the mechanism of action of Fusidic acid?

A

Inhibition of protein synthesis

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13
Q

What is the mode of action of Sulphonamides?

A

Bacteriostatic

Combo: Time-dependent bactericidal

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14
Q

What is the mechanism of action of Sulphonamides?

A

Inhibition of folic acid synthesis

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15
Q

What is the mode of action of Diaminopyrimidines?

A

Bacteriostatic

Combo: Time-dependent bactericidal

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16
Q

What is the mechanism of action of Diaminopyrimidines?

A

Inhibition of folic acid synthesis

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17
Q

What is the mode of action of Fluoroquinolones?

A

Concentration-dependent bactericidal

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18
Q

What is the mechanism of action of Fluoroquinolones?

A

Inhibition of DNA synthesis

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19
Q

What is the mode of action of Nitrofurans?

A

Bactericidal

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20
Q

What is the mechanism of action of Nitrofurans?

A

Destroys the DNA of bacteria

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21
Q

What is the mode of action of Nitroimidazoles?

A

Concentration-dependent bactericidal

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22
Q

What is the mechanism of action of Nitroimidazoles?

A

Destroys the DNA of bacteria

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23
Q

List the Polypeptide ABs

A

Bacitracin
Polymyxin B
Polymyxin E (Colistin)

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24
Q

List the Glycopeptide ABs

A

Vancomycin

Teicoplanin

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25
Q

List the Rifamycins

A

Rifampicin

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26
Q

List the Pseudomonic acids

A

Muciprocin

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27
Q

List the Phosphonic acid derivatives

A

Fosfomycin

28
Q

List the Fusidic acids

A

Fusidic acid

29
Q

List the Sulphonamides

A 
Sulfadimidine
Sulfadiazine
Sulfachlorpyrazine
Sulfamethoxasole
Sulfadoxine
Sulfaquinoxaline
Sulfasalazine
30
Q

What is the mode of action of Sulphonamides in combinations?

A

Time-dependent bactericidal

31
Q

List the 1st Generation Fluoroquinolones

A

Nalidixic acid

32
Q

List the 2nd Generation Fluoroquinolones

A 
Flumequine
Norfloxacin
Orbifloxacin
Ciprofloxacin
Enrofloxacin
Danofloxacin
Difloxacin
Marbofloxacin
33
Q

List the 3rd Generation Fluoroquinolones

A

Levofloxacin

Sparfloxacin

34
Q

List the 4th Generation Fluoroquinolones

A

Pradofloxacin

Moxifloxacin

35
Q

List the Nitrofurans’

A

Nitrofurantoin

Furazolidone

36
Q

List the Nitroimidazoles

A

Metronidazole
Ronidazole
Tinidazole

37
Q

List the Diaminopyrimidines

A

Trimethoprim

Baquiloprim

38
Q

Enrofloxacin belongs to which AMEG group?

A

AMEG B

39
Q

How would you describe the pharmacokinetic properties of Colistin?

A

Adsorption of Colistin is very slow from GI tract

40
Q

Ornithobacterium rhinotracheale is frequently resistant to this antibiotic…?

A

Difloxacin

41
Q

This agent is effective against Actinobacillus suis and Mycoplasma hyopneumoniae in swine?

A

Enrofloxacin IM, Tulathromycin IM and Lincomycin-Spectinomycin combination IM

42
Q

Which drug can be used for systemic treatment of MRSP pyoderma in dogs?

A

Rifampicin

43
Q

True or False:
Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine and it is outstanding activity against Mycoplasma species.

A

True

44
Q

True or False:

Oral sulphonamide-trimethoprim combinations are particularly effective against mycoplasmas in poultry species.

A

False

45
Q

True or False:
Acquired resistance to fluoroquinolone in pathogenic bacteria develops gradually and in several stages only after several weeks of treatment.

A

False

46
Q

True or False:
For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations.

A

False

47
Q

True or False:

Consumption of colistin should be decreased in veterinary practice

A

True

48
Q

What is the route of administration for colistin in swine?

A

PO

49
Q

True or False:

Consumption of fluoroquinolones should be decreased in veterinary practice

A

True

50
Q

Nalidixic acid belongs to the…

A

1st Generation FQ

51
Q

Metronidazole belongs to the…

A

Nitroimidazoles

52
Q

Which drug combination would be recommended to treat aspiration pneumonia in dogs?

A

Amoxicillin + marbofloxacin + metronidazole

53
Q

Which AMEG group does Colistin belong to?

A

AMEG B

54
Q

What can be effective against MRSP pyoderma in dogs?

A

Fusidic acid

55
Q

True or False:

Fluoroquinolones can be used as first line treatment of chronic rhinitis in dogs or cats.

A

True (except Pradofloxacin)

56
Q

Which antibiotic combinations would be recommended in pneumonia in dogs?

A

Cefuroxime + Marbofloxacin

AmoxiClav + Enrofloxacin

57
Q

Polymyxins are…

A

Glycopeptide ABs: Vancomycin, Teiocoplanin

Polypeptide ABs: Bacitracin, Polymyxin B, Polymyxin E (Colsitin)

58
Q

Enrofloxacin belongs to…

A

2nd Generation FQ

59
Q

Which AMEG group does Marbofloxacin belong to?

A

AMEG B

60
Q

What is the route of administration for marbofloxacin in swine?

A

IM

61
Q

Which drugs can be effective against MRSP?

A

Muciprocin

62
Q

True or False:

In case of a damaged eardrum, Tobramycin and Marbofloxacin ear drops can be used, because only Polymyxins are ototoxic.

A

False (Polymyxins AND Gentamicin is ototoxic)

63
Q

Pradofloxacin belongs to…

A

4th Generation FQ

64
Q

What is the route of administration of Enrofloxacin in swine?

A

PO + IM

65
Q

Which drug can be used topically to treat canine pyoderma?

A

Silver sulfadiazine

66
Q

When are Fluoroquinolones first choice ABs?

A

Cow acute mastitis

Dog prostatitis

Prudent Use of AB (5 decks)

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