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Prudent Use of AB > Peptide ABs, Sulphonamides, Diaminopyrimidines, FQs etc. > Flashcards

Peptide ABs, Sulphonamides, Diaminopyrimidines, FQs etc. Flashcards

1
Q

What is the mode of action of Polypeptide ABs?

A

Concentration-dependent bactericidal

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2
Q

What is the mechanism of action of Polypeptide ABs?

A

Act like cationic detergent

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3
Q

What is the mode of action of Glycopeptide ABs?

A

Time-dependent bactericidal

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4
Q

What is the mechanism of action of Glycopeptide ABs?

A

Inhibition of cell wall synthesis

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5
Q

What is the mode of action of Rifamycins?

A

Time-dependent bactericidal

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6
Q

What is the mechanism of action of Rifamycins?

A

Inhibit bacterial DNA-dependent RNA polymerase

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7
Q

What is the mode of action of Pseudomonic acid?

A

Bactericidal

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8
Q

What is the mechanism of action of Pseudomonic acid?

A

Inhibition of cell wall synthesis

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9
Q

What is the mode of action of Phosphonic acid derivatives?

A

Bactericidal

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10
Q

What is the mechanism of action of Phosphonic acid derivatives?

A

Inhibition of cell wall synthesis

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11
Q

What is the mode of action of Fusidic acid?

A

Bacteriostatic

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12
Q

What is the mechanism of action of Fusidic acid?

A

Inhibition of protein synthesis

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13
Q

What is the mode of action of Sulphonamides?

A

Bacteriostatic

Combo: Time-dependent bactericidal

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14
Q

What is the mechanism of action of Sulphonamides?

A

Inhibition of folic acid synthesis

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15
Q

What is the mode of action of Diaminopyrimidines?

A

Bacteriostatic

Combo: Time-dependent bactericidal

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16
Q

What is the mechanism of action of Diaminopyrimidines?

A

Inhibition of folic acid synthesis

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17
Q

What is the mode of action of Fluoroquinolones?

A

Concentration-dependent bactericidal

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18
Q

What is the mechanism of action of Fluoroquinolones?

A

Inhibition of DNA synthesis

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19
Q

What is the mode of action of Nitrofurans?

A

Bactericidal

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20
Q

What is the mechanism of action of Nitrofurans?

A

Destroys the DNA of bacteria

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21
Q

What is the mode of action of Nitroimidazoles?

A

Concentration-dependent bactericidal

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22
Q

What is the mechanism of action of Nitroimidazoles?

A

Destroys the DNA of bacteria

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23
Q

List the Polypeptide ABs

A

Bacitracin
Polymyxin B
Polymyxin E (Colistin)

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24
Q

List the Glycopeptide ABs

A

Vancomycin

Teicoplanin

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25
List the Rifamycins
Rifampicin
26
List the Pseudomonic acids
Muciprocin
27
List the Phosphonic acid derivatives
Fosfomycin
28
List the Fusidic acids
Fusidic acid
29
List the Sulphonamides
``` Sulfadimidine Sulfadiazine Sulfachlorpyrazine Sulfamethoxasole Sulfadoxine Sulfaquinoxaline Sulfasalazine ```
30
What is the mode of action of Sulphonamides in combinations?
Time-dependent bactericidal
31
List the 1st Generation Fluoroquinolones
Nalidixic acid
32
List the 2nd Generation Fluoroquinolones
``` Flumequine Norfloxacin Orbifloxacin Ciprofloxacin Enrofloxacin Danofloxacin Difloxacin Marbofloxacin ```
33
List the 3rd Generation Fluoroquinolones
Levofloxacin | Sparfloxacin
34
List the 4th Generation Fluoroquinolones
Pradofloxacin | Moxifloxacin
35
List the Nitrofurans'
Nitrofurantoin | Furazolidone
36
List the Nitroimidazoles
Metronidazole Ronidazole Tinidazole
37
List the Diaminopyrimidines
Trimethoprim | Baquiloprim
38
Enrofloxacin belongs to which AMEG group?
AMEG B
39
How would you describe the pharmacokinetic properties of Colistin?
Adsorption of Colistin is very slow from GI tract
40
Ornithobacterium rhinotracheale is frequently resistant to this antibiotic…?
Difloxacin
41
This agent is effective against Actinobacillus suis and Mycoplasma hyopneumoniae in swine?
Enrofloxacin IM, Tulathromycin IM and Lincomycin-Spectinomycin combination IM
42
Which drug can be used for systemic treatment of MRSP pyoderma in dogs?
Rifampicin
43
True or False: Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine and it is outstanding activity against Mycoplasma species.
True
44
True or False: | Oral sulphonamide-trimethoprim combinations are particularly effective against mycoplasmas in poultry species.
False
45
True or False: Acquired resistance to fluoroquinolone in pathogenic bacteria develops gradually and in several stages only after several weeks of treatment.
False
46
True or False: For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations.
False
47
True or False: | Consumption of colistin should be decreased in veterinary practice
True
48
What is the route of administration for colistin in swine?
PO
49
True or False: | Consumption of fluoroquinolones should be decreased in veterinary practice
True
50
Nalidixic acid belongs to the...
1st Generation FQ
51
Metronidazole belongs to the...
Nitroimidazoles
52
Which drug combination would be recommended to treat aspiration pneumonia in dogs?
Amoxicillin + marbofloxacin + metronidazole
53
Which AMEG group does Colistin belong to?
AMEG B
54
What can be effective against MRSP pyoderma in dogs?
Fusidic acid
55
True or False: | Fluoroquinolones can be used as first line treatment of chronic rhinitis in dogs or cats.
True (except Pradofloxacin)
56
Which antibiotic combinations would be recommended in pneumonia in dogs?
Cefuroxime + Marbofloxacin | AmoxiClav + Enrofloxacin
57
Polymyxins are...
Glycopeptide ABs: Vancomycin, Teiocoplanin | Polypeptide ABs: Bacitracin, Polymyxin B, Polymyxin E (Colsitin)
58
Enrofloxacin belongs to...
2nd Generation FQ
59
Which AMEG group does Marbofloxacin belong to?
AMEG B
60
What is the route of administration for marbofloxacin in swine?
IM
61
Which drugs can be effective against MRSP?
Muciprocin
62
True or False: | In case of a damaged eardrum, Tobramycin and Marbofloxacin ear drops can be used, because only Polymyxins are ototoxic.
False (Polymyxins AND Gentamicin is ototoxic)
63
Pradofloxacin belongs to...
4th Generation FQ
64
What is the route of administration of Enrofloxacin in swine?
PO + IM
65
Which drug can be used topically to treat canine pyoderma?
Silver sulfadiazine
66
When are Fluoroquinolones first choice ABs?
Cow acute mastitis | Dog prostatitis

Prudent Use of AB (5 decks)

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