Aminoglycosides, TTCs, Macrolides, Lincosamides, Pleuromutilins, Phenicols

Question 1

What is the mechanism of action of Aminoglycosides?

Answer 1

Inhibition of protein synthesis (30s subunit)

Mistranslation

Question 2

What is the mode of action of Aminoglycosides?

Answer 2

Concentration dependent bactericidal

Question 3

What is the mechanism of action of Tetracyclines?

Answer 3

Inhibition of protein synthesis (30s subunit)

Question 4

What is the mode of action of Pleuromutilins?

Answer 4

Bacteriostatic

Question 5

List the short-acting TTCs

Answer 5

Chlortetracycline
Oxytetracycline
Tetracycline

Question 6

List the long-acting TTCs

Answer 6

Doxycycline

Minocycline

Question 7

What is the mechanism of action of Macrolides?

Answer 7

Inhibition of protein synthesis (50s subunit)

Question 8

What is the mechanism of action of Lincosamides?

Answer 8

Inhibition of protein synthesis (50s subunit)

Question 9

What is the mechanism of action of Pleuromutilins?

Answer 9

Inhibition of protein synthesis (50s subunit)

Question 10

What is the mechanism of action of Phenicols?

Answer 10

Inhibition of protein synthesis (50s subunit)

Question 11

List the Aminoglycosides (9)

Answer 11

Streptomycin
Spectinomycin
Amikacin
Apramycin
Gentamicin
Kanaymcin
Neomycin
Paromomicin
Tobramycin

Question 12

What is the mode of action of Spectinomycin?

Answer 12

Bacteriostatic

Question 13

Mistranslation is specific for which group of antibiotics?

Answer 13

Aminoglycosides

Question 14

Mistranslation is specific for which group of antibiotics?

Answer 14

Aminoglycosides

Question 15

List the Macrolides (10)

Answer 15

Azithromycin
Clarithromycin
Erythromycin
Gamithromycin
Spiramycin
Tulathromycin
Tylosin
Tylvalosin
Tilmicosin
Tildipirosin

Question 16

List the Lincosamides

Answer 16

Lincomycin

Clindamycin

Question 17

List the Pleuromutilins

Answer 17

Tiamulin

Valnemulin

Question 18

List the Phenicols

Answer 18

Chloramphenicol
Florfenicol
Thiamphenicol

Question 19

List the Phenicols

Answer 19

Chloramphenicol
Florfenicol
Thiamphenicol

Question 20

Valnemulin belongs to?

Answer 20

Pleuromutilins

Question 21

Pleuromutilins are…

Answer 21

Bacteriostatics

Inhibit protein synthesis 50s subunit

Question 22

Which drug belongs to the first line choice systemic treatment for canine pyoderma?

Answer 22

Clindamycin

Question 23

What is the route of admin of Tilmicosin for swine?

Answer 23

PO

Question 24

Which agent is first line choice in chronic rhinitis in dogs or cats?
A) Azithromycin
B) Doxycycline
C) Both of them
D) None of them

Answer 24

C) Both of them

Question 25

What is the route of admin of Tilmicosin for swine?

Answer 25

PO

Question 26

Amikacin belongs to...

Answer 26

Aminoglycosides

Question 27

Spectinomycin belongs to...

Answer 27

Aminiglycosides but it is a bacteriostatic

Question 28

Which drug can be used topically to treat canine pyoderma?

Answer 28

Neomycin

Question 29

Minocycline belongs to...

Answer 29

Long-acting TTC

Question 30

Tulathromycin belongs to...

Answer 30

Macrolides

Question 31

Clindamycin belongs to...

Answer 31

Lincosamides

Question 32

Gamithromycin belongs to...

Answer 32

Macrolides

Question 33

Neomycin belongs to...

Answer 33

Aminoglycosides

Question 34

This drug is very effective against fastidious bacteria and Mycoplasma as well and has excellent distribution?

Answer 34

Gamithromycin

Question 35

Florfenicol can have this side effect in dogs?

Answer 35

Anaemia followed by neutropenia after long-term use

Question 36

True or False: Poultry feed cannot contain Narazin if the animals are treated with Tiamulin, because the CYP inhibitory activity of Narazin can lead to severe toxic interaction?

Answer 36

True

Question 37

True or False: | Florfenicol is NOT authorised for poultry in the EU.

Answer 37

True

Question 38

True or False: | Chloramphenicol is NOT authorised for poultry in the EU.

Answer 38

True

Question 39

True or False: Florfenicol and Tiamulin combination is synergistic against Ornithobacterium rhinotracheale, because they inhibit protein synthesis on different targets?

Answer 39

False

Question 40

Which antibiotic group reaches the highest concentrations intracellularly (e.g. macrophages)?

Answer 40

Macrolides

Question 41

What is the route of admin of Lincomycin for swine?

Answer 41

IM

Question 42

Which AMEG group does Lincomycin belong to?

Answer 42

AMEG C

Question 43

What is Tiamulin?

Answer 43

Pleuromutilin

Question 44

What is Erythromycin?

Answer 44

Macrolide

Question 45

Doxycycline belongs to?

Answer 45

Long-acting TTC

Question 46

Aminoglycosides are...?

Answer 46

Concentration-dependent bactericidal EXCEPT Spectinomycin which is a bacteriostatic

Question 47

What admin route can Amikacin be given to treat canine pyoderma?

Answer 47

IM

Question 48

``` What can be first choice in CIRDC? A) Doxycycline B) Potentiated SA C) Both of them D) None of them ```

Answer 48

C) Both of them

Question 49

True or False: Lincomycin and Florfenicol can be used to treat foot rot, as it is active against anaerobic bacteria and its penetration is good.

Answer 49

True

Question 50

``` What can be first choice in CIRDC? A) Doxycycline B) Clarithromycin C) Both of them D) None of them ```

Answer 50

C) Both of them

Question 51

True or False: | Amikacin can be effective against MRSP?

Answer 51

True

Question 52

True or False: | Amikacin can be effective against MRSP?

Answer 52

True

Question 53

Which AMEG group does Gentamicin belong to?

Answer 53

AMEG C

Question 54

How would you describe the pharmacokinetic properties of Gentamicin?

Answer 54

Very slow absorption from GI tract

Question 55

Ornithobacterium rhinotracheale is frequently resistant to this antibiotic…?

Answer 55

Tylosin

Question 56

This agent is effective against Actinobacillus suis and Mycoplasma hyopneumoniae in swine?

Answer 56

Enrofloxacin IM Tulathromycin IM Lincomycin-Spectinomycin combination IM

Question 57

What is the route of administration for gamithromycin in swine?

Answer 57

IM

Question 58

Which agent would be first-line choice in chronic pharyngitis in dogs?

Answer 58

Azithromycin

Question 59

True or False: | Tulathromycin can reach effective concentration in lung and this concentration persist in lung until one week

Answer 59

True

Question 60

True or False: Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine and it is outstanding activity against Mycoplasma species.

Answer 60

True

Question 61

True or False: | The efficacy of oral chlortetracycline against mycoplasmas in poultry species is uncertain due to poor absorption.

Answer 61

True

Question 62

True or False: | In poultry species, Tilmicosin may be most effective in treating diseases caused by Spirochaeta spp.

Answer 62

False

Question 63

True or False: In case of ruminant Porphyromonas levii interdigital dermatitis, although the substance can be present at the site of infection in high concentrations, using tetracycline locally is not advised due to the bacterial resistance against the substance.

Answer 63

False

Question 64

True or False: For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations.

Answer 64

False