Aminoglycosides, TTCs, Macrolides, Lincosamides, Pleuromutilins, Phenicols Flashcards
What is the mechanism of action of Aminoglycosides?
Inhibition of protein synthesis (30s subunit)
Mistranslation
What is the mode of action of Aminoglycosides?
Concentration dependent bactericidal
What is the mechanism of action of Tetracyclines?
Inhibition of protein synthesis (30s subunit)
What is the mode of action of Pleuromutilins?
Bacteriostatic
List the short-acting TTCs
Chlortetracycline
Oxytetracycline
Tetracycline
List the long-acting TTCs
Doxycycline
Minocycline
What is the mechanism of action of Macrolides?
Inhibition of protein synthesis (50s subunit)
What is the mechanism of action of Lincosamides?
Inhibition of protein synthesis (50s subunit)
What is the mechanism of action of Pleuromutilins?
Inhibition of protein synthesis (50s subunit)
What is the mechanism of action of Phenicols?
Inhibition of protein synthesis (50s subunit)
List the Aminoglycosides (9)
Streptomycin Spectinomycin Amikacin Apramycin Gentamicin Kanaymcin Neomycin Paromomicin Tobramycin
What is the mode of action of Spectinomycin?
Bacteriostatic
Mistranslation is specific for which group of antibiotics?
Aminoglycosides
Mistranslation is specific for which group of antibiotics?
Aminoglycosides
List the Macrolides (10)
Azithromycin Clarithromycin Erythromycin Gamithromycin Spiramycin Tulathromycin Tylosin Tylvalosin Tilmicosin Tildipirosin
List the Lincosamides
Lincomycin
Clindamycin
List the Pleuromutilins
Tiamulin
Valnemulin
List the Phenicols
Chloramphenicol
Florfenicol
Thiamphenicol
List the Phenicols
Chloramphenicol
Florfenicol
Thiamphenicol
Valnemulin belongs to?
Pleuromutilins
Pleuromutilins are…
Bacteriostatics
Inhibit protein synthesis 50s subunit
Which drug belongs to the first line choice systemic treatment for canine pyoderma?
Clindamycin
What is the route of admin of Tilmicosin for swine?
PO
Which agent is first line choice in chronic rhinitis in dogs or cats? A) Azithromycin B) Doxycycline C) Both of them D) None of them
C) Both of them
What is the route of admin of Tilmicosin for swine?
PO
Amikacin belongs to…
Aminoglycosides
Spectinomycin belongs to…
Aminiglycosides but it is a bacteriostatic
Which drug can be used topically to treat canine pyoderma?
Neomycin
Minocycline belongs to…
Long-acting TTC
Tulathromycin belongs to…
Macrolides
Clindamycin belongs to…
Lincosamides
Gamithromycin belongs to…
Macrolides
Neomycin belongs to…
Aminoglycosides
This drug is very effective against fastidious bacteria and Mycoplasma as well and has excellent distribution?
Gamithromycin
Florfenicol can have this side effect in dogs?
Anaemia followed by neutropenia after long-term use
True or False:
Poultry feed cannot contain Narazin if the animals are treated with Tiamulin, because the CYP inhibitory activity of Narazin can lead to severe toxic interaction?
True
True or False:
Florfenicol is NOT authorised for poultry in the EU.
True
True or False:
Chloramphenicol is NOT authorised for poultry in the EU.
True
True or False:
Florfenicol and Tiamulin combination is synergistic against Ornithobacterium rhinotracheale, because they inhibit protein synthesis on different targets?
False
Which antibiotic group reaches the highest concentrations intracellularly (e.g. macrophages)?
Macrolides
What is the route of admin of Lincomycin for swine?
IM
Which AMEG group does Lincomycin belong to?
AMEG C
What is Tiamulin?
Pleuromutilin
What is Erythromycin?
Macrolide
Doxycycline belongs to?
Long-acting TTC
Aminoglycosides are…?
Concentration-dependent bactericidal EXCEPT Spectinomycin which is a bacteriostatic
What admin route can Amikacin be given to treat canine pyoderma?
IM
What can be first choice in CIRDC? A) Doxycycline B) Potentiated SA C) Both of them D) None of them
C) Both of them
True or False:
Lincomycin and Florfenicol can be used to treat foot rot, as it is active against anaerobic bacteria and its penetration is good.
True
What can be first choice in CIRDC? A) Doxycycline B) Clarithromycin C) Both of them D) None of them
C) Both of them
True or False:
Amikacin can be effective against MRSP?
True
True or False:
Amikacin can be effective against MRSP?
True
Which AMEG group does Gentamicin belong to?
AMEG C
How would you describe the pharmacokinetic properties of Gentamicin?
Very slow absorption from GI tract
Ornithobacterium rhinotracheale is frequently resistant to this antibiotic…?
Tylosin
This agent is effective against Actinobacillus suis and Mycoplasma hyopneumoniae in swine?
Enrofloxacin IM
Tulathromycin IM
Lincomycin-Spectinomycin combination IM
What is the route of administration for gamithromycin in swine?
IM
Which agent would be first-line choice in chronic pharyngitis in dogs?
Azithromycin
True or False:
Tulathromycin can reach effective concentration in lung and this concentration persist in lung until one week
True
True or False:
Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine and it is outstanding activity against Mycoplasma species.
True
True or False:
The efficacy of oral chlortetracycline against mycoplasmas in poultry species is uncertain due to poor absorption.
True
True or False:
In poultry species, Tilmicosin may be most effective in treating diseases caused by Spirochaeta spp.
False
True or False:
In case of ruminant Porphyromonas levii interdigital dermatitis, although the substance can be present at the site of infection in high concentrations, using tetracycline locally is not advised due to the bacterial resistance against the substance.
False
True or False:
For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations.
False
