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Prudent Use of AB > Aminoglycosides, TTCs, Macrolides, Lincosamides, Pleuromutilins, Phenicols > Flashcards

Aminoglycosides, TTCs, Macrolides, Lincosamides, Pleuromutilins, Phenicols Flashcards

1
Q

What is the mechanism of action of Aminoglycosides?

A

Inhibition of protein synthesis (30s subunit)

Mistranslation

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2
Q

What is the mode of action of Aminoglycosides?

A

Concentration dependent bactericidal

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3
Q

What is the mechanism of action of Tetracyclines?

A

Inhibition of protein synthesis (30s subunit)

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4
Q

What is the mode of action of Pleuromutilins?

A

Bacteriostatic

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5
Q

List the short-acting TTCs

A

Chlortetracycline
Oxytetracycline
Tetracycline

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6
Q

List the long-acting TTCs

A

Doxycycline

Minocycline

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7
Q

What is the mechanism of action of Macrolides?

A

Inhibition of protein synthesis (50s subunit)

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8
Q

What is the mechanism of action of Lincosamides?

A

Inhibition of protein synthesis (50s subunit)

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9
Q

What is the mechanism of action of Pleuromutilins?

A

Inhibition of protein synthesis (50s subunit)

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10
Q

What is the mechanism of action of Phenicols?

A

Inhibition of protein synthesis (50s subunit)

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11
Q

List the Aminoglycosides (9)

A 
Streptomycin
Spectinomycin
Amikacin
Apramycin
Gentamicin
Kanaymcin
Neomycin
Paromomicin
Tobramycin
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12
Q

What is the mode of action of Spectinomycin?

A

Bacteriostatic

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13
Q

Mistranslation is specific for which group of antibiotics?

A

Aminoglycosides

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14
Q

Mistranslation is specific for which group of antibiotics?

A

Aminoglycosides

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15
Q

List the Macrolides (10)

A 
Azithromycin
Clarithromycin
Erythromycin
Gamithromycin
Spiramycin
Tulathromycin
Tylosin
Tylvalosin
Tilmicosin
Tildipirosin
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16
Q

List the Lincosamides

A

Lincomycin

Clindamycin

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17
Q

List the Pleuromutilins

A

Tiamulin

Valnemulin

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18
Q

List the Phenicols

A

Chloramphenicol
Florfenicol
Thiamphenicol

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19
Q

List the Phenicols

A

Chloramphenicol
Florfenicol
Thiamphenicol

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20
Q

Valnemulin belongs to?

A

Pleuromutilins

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21
Q

Pleuromutilins are…

A

Bacteriostatics

Inhibit protein synthesis 50s subunit

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22
Q

Which drug belongs to the first line choice systemic treatment for canine pyoderma?

A

Clindamycin

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23
Q

What is the route of admin of Tilmicosin for swine?

A

PO

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24
Q 
Which agent is first line choice in chronic rhinitis in dogs or cats?
A) Azithromycin
B) Doxycycline
C) Both of them
D) None of them
A

C) Both of them

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25
Q

What is the route of admin of Tilmicosin for swine?

A

PO

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26
Q

Amikacin belongs to…

A

Aminoglycosides

27
Q

Spectinomycin belongs to…

A

Aminiglycosides but it is a bacteriostatic

28
Q

Which drug can be used topically to treat canine pyoderma?

A

Neomycin

29
Q

Minocycline belongs to…

A

Long-acting TTC

30
Q

Tulathromycin belongs to…

A

Macrolides

31
Q

Clindamycin belongs to…

A

Lincosamides

32
Q

Gamithromycin belongs to…

A

Macrolides

33
Q

Neomycin belongs to…

A

Aminoglycosides

34
Q

This drug is very effective against fastidious bacteria and Mycoplasma as well and has excellent distribution?

A

Gamithromycin

35
Q

Florfenicol can have this side effect in dogs?

A

Anaemia followed by neutropenia after long-term use

36
Q

True or False:
Poultry feed cannot contain Narazin if the animals are treated with Tiamulin, because the CYP inhibitory activity of Narazin can lead to severe toxic interaction?

A

True

37
Q

True or False:

Florfenicol is NOT authorised for poultry in the EU.

A

True

38
Q

True or False:

Chloramphenicol is NOT authorised for poultry in the EU.

A

True

39
Q

True or False:
Florfenicol and Tiamulin combination is synergistic against Ornithobacterium rhinotracheale, because they inhibit protein synthesis on different targets?

A

False

40
Q

Which antibiotic group reaches the highest concentrations intracellularly (e.g. macrophages)?

A

Macrolides

41
Q

What is the route of admin of Lincomycin for swine?

A

IM

42
Q

Which AMEG group does Lincomycin belong to?

A

AMEG C

43
Q

What is Tiamulin?

A

Pleuromutilin

44
Q

What is Erythromycin?

A

Macrolide

45
Q

Doxycycline belongs to?

A

Long-acting TTC

46
Q

Aminoglycosides are…?

A

Concentration-dependent bactericidal EXCEPT Spectinomycin which is a bacteriostatic

47
Q

What admin route can Amikacin be given to treat canine pyoderma?

A

IM

48
Q 
What can be first choice in CIRDC?
A) Doxycycline
B) Potentiated SA
C) Both of them
D) None of them
A

C) Both of them

49
Q

True or False:
Lincomycin and Florfenicol can be used to treat foot rot, as it is active against anaerobic bacteria and its penetration is good.

A

True

50
Q 
What can be first choice in CIRDC?
A) Doxycycline
B) Clarithromycin
C) Both of them
D) None of them
A

C) Both of them

51
Q

True or False:

Amikacin can be effective against MRSP?

A

True

52
Q

True or False:

Amikacin can be effective against MRSP?

A

True

53
Q

Which AMEG group does Gentamicin belong to?

A

AMEG C

54
Q

How would you describe the pharmacokinetic properties of Gentamicin?

A

Very slow absorption from GI tract

55
Q

Ornithobacterium rhinotracheale is frequently resistant to this antibiotic…?

A

Tylosin

56
Q

This agent is effective against Actinobacillus suis and Mycoplasma hyopneumoniae in swine?

A

Enrofloxacin IM
Tulathromycin IM
Lincomycin-Spectinomycin combination IM

57
Q

What is the route of administration for gamithromycin in swine?

A

IM

58
Q

Which agent would be first-line choice in chronic pharyngitis in dogs?

A

Azithromycin

59
Q

True or False:

Tulathromycin can reach effective concentration in lung and this concentration persist in lung until one week

A

True

60
Q

True or False:
Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine and it is outstanding activity against Mycoplasma species.

A

True

61
Q

True or False:

The efficacy of oral chlortetracycline against mycoplasmas in poultry species is uncertain due to poor absorption.

A

True

62
Q

True or False:

In poultry species, Tilmicosin may be most effective in treating diseases caused by Spirochaeta spp.

A

False

63
Q

True or False:
In case of ruminant Porphyromonas levii interdigital dermatitis, although the substance can be present at the site of infection in high concentrations, using tetracycline locally is not advised due to the bacterial resistance against the substance.

A

False

64
Q

True or False:
For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations.

A

False

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