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28 GI drugs > Peptic ulcer disease > Flashcards

Peptic ulcer disease Flashcards

1
Q

Which groups of drugs can be used for peptic ulcer disease? (5 groups)

A 
Histamine H2 antagonists
Proton pump inhibitors
Antacids
Cytoprotective drugs
Antibiotics
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2
Q

H2 blockers (4 drugs)

A

Cimetidine
Famotidine
Ranitidine
Nizatidine

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3
Q

H2 blockers - MOA

A

Inhibition of gastric acid and pepsin secretion

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4
Q

H2 blockers - indications

A

PUD, GERD, dyspepsia.

Allergy (combo with H1 blocker)

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5
Q

Cimetidine - adverse effects, and why

A

Gynecomastia in men because of antiandrogenic activity

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6
Q

Cimetidine - interactions (10 drugs)

A

Decreased metabolism of alprazolam, carbamazepine, cisapride, disopyramide, felodipine, lovastatin, phenytoin, saquinavir, triazolam, warfarin

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7
Q

PPIs - MOA

A

Irreversible inhibition of proton pumps.

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8
Q

PPIs (5 drugs)

A 
Esomeprazole
Omeprazole
Pantoprazole
Rabeprazole
Lanzoprazole
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9
Q

PPIs - indications

A

PUD, GERD, Zollinger-Ellison syndrome. NSAID treatment

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10
Q

Drug of choice for Zollinger-Ellison syndrome (group)

A

PPIs

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11
Q

PPIs - adverse effects

A

Hypomagnesemia (long treatment)

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12
Q

Antacids (3 drugs)

A

Aluminum hydroxide
Magnesium hydroxide
Calcium bicarbonate

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13
Q

Which antacids are usually combined, and why?

A

Aluminum hydroxide + magnesium hydroxide.

Prevents side effects

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14
Q

Aluminum hydroxide - adverse effect

A

Constipation

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15
Q

Magnesium hydroxide - adverse effects

A

Diarrhea

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16
Q

Which group of drugs are seldom used for PUD?

a) H2 blockes
b) PPIs
c) antacids
d) cytoprotecitve drugs
e) antibiotics

A

Antacids

17
Q

Cytoprotective drugs (2 drugs)

A

Sucralfate

Misoprostol

18
Q

Sucralfate - MOA

A

Forms cytoprotective barrier by inhibiting pepsin catalyzed hydrolysis and stimulation of prostaglandin synthesis.

19
Q

When is sucralfate used for PUD?

A

When H2 blockers or PPIs are not tolerated

20
Q

Sucralfate - Adverse effects

A

Laryngospasm

21
Q

Misoprostol - MOA as GI drug

A

Inh acid secretion. Stimulates mucus and bicarbonate secretion

22
Q

Misoprostol (as GI drug) is espesically used for

A

NSAID treatment: prevention of ulcers

23
Q

Misoprostol - adverse effects

A

Uterine contractions

24
Q

Drugs against H. pylori

A

Amoxicillin, clarithromycin, metronidazole, tinidazole, bismuth subsalicylate, tetracycline

28 GI drugs (5 decks)

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