Antiemetics

Question 1

Antiemetic (4 groups)

Answer 1

Serotonin 5-HT3 antagonists
Dopamine D2 antagonists
Neurokinin-1 antagonists
Histamine H1 antagonists

Question 2

Antiemetic 5-HT3 antagonists for antiemetisis (4 drugs)

Answer 2

Ondansetron
Granisetron
Dolasetron
Palonosetron

Question 3

Drug with synergistic activity to 5-HT3 antagonists

Answer 3

Dexamethasone

Question 4

Serotonin 5-HT3 antagonists - MOA

Answer 4

Competitive inhibition of receptors on vagal afferent nerves, solitary tract nucleus and CTZ. (prevents peripheral and central stimulation of vomiting center)

Question 5

Ondansetron - adverse effects

Answer 5

Anaphylactoid reaction: bronchospasm, angioedema, hypotension, urticaria

Question 6

The 5-HT3 antagonists are mainly used for which type of emesis?

Answer 6

Chemotherapy induced emesis

Question 7

D2 antagonists used for emesis (3 drugs)

Answer 7

Metoclopramide
Phenothiazine drugs (prochlorperazine + perphenazine)

Question 8

Phenothiazine drugs - indications

Answer 8

Pt who is unable to take oral medication

Question 9

Neurokinin-1 receptor antagonists used for emesis (1 drug)

Answer 9

Aprepitant

Question 10

Dronabinol - indications

Answer 10

Alternative antiemetic.

Appetite stimulant in AIDS

Question 11

H1 antagonists used as antiemetics (3 drugs)

Answer 11

Dimenhydrinate
Meclizine
Promethazine

Question 12

Drugs used for motion sichness (3 drugs)

Answer 12

Dimenhydrinate
Meclizine
Scopolamine

Question 13

Antiemetic drug used with highly emetic chemotherapy (cisplatin)

Answer 13

Aprepitant