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Y Biochemistry 2 > Pentose Phosphate Pathway (Ben) > Flashcards

Pentose Phosphate Pathway (Ben) Flashcards

1
Q

What are the two main functions of the pentose phosphate pathway?

A
  1. Formation of NADPH
  2. Synthesis of Ribose-5-P
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2
Q

What are the two main functions of the NADPH created by the pentose phosphate pathway?

A

Synthesis of…

  • Fatty acids
  • Cholesterol
  • NTs
  • Nucleotides

Detoxification …

  • reducing oxidized Glutathione
  • Cytochrome P450 enzymes
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3
Q

What is the function of ribose created by the pentose phosphate pathway?

A

Nucleotide and nucleic acid formation

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4
Q

Where does the pentose phosphate pathway occur?

A

cytosol

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5
Q

What are the two phases of the pentose phosphate pathway?

Their main substrates and products?

A
  1. Irreversible Oxidative Phase
    • substrate: G6P
    • product: ribulose-5-phosphate + NADPH
  2. Reversible Nonoxidative Phase
    • substrate: ribulose-5-phosphate
    • product: G6P + Ribose Precursors
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6
Q

What is the 1st reaction of the pentose phosphate pathway?

Substrates?

Enzyme?

Product?

Note?

A

Dehydrogenation…

Substrate: G6P + NADP+

Enzyme: G6P Dehydrogenase

Product: 6-Phosphogluconolactone

Note: IRREVERSIBLE

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7
Q

What is the 2nd reaction of the PP pathway?

Substrate?

Enzyme?

Product?

Note?

A

Hydrolysis…

Substrate: 6-Phosphogluconolactone

Enzyme: Lactonase

Product: 6-Phosphogluconolactate

Note: IRREVERSIBLE​

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8
Q

What is the 3rd reaction of the PP Pathway (ignoring the intermediate) ?

Substrate?

Enzyme?

Product?

Note?

A

Oxidative decarboxylation…

Substrate: 6-Phosphogluconolactate + NADP+

Enzyme: 6-Phosphogluconolactate Dehydrogenase

Product: Ribulose-5-phosphate + NADPH + H+ + CO2

Note: IRREVERSIBLE​

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9
Q

What is the main disease associated with PP pathway dysfunction?

What is its main symptom and how is it triggered?

A

G6P Dehydrogenase Deficiency or Favism

  • mainly characterized by hemolytic anemia
  • symptoms brought on by oxidative stress (infection, some drugs, fava beans)
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Y Biochemistry 2 (24 decks)

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