Pentose Phosphate Pathway Flashcards
The pentose phosphate pathway (PPP) is also known as the ____ ____ shunt
hexose monophosphate
PPP diverts __1___ from glycolysis in order to form __2___, __2__, and glycolytic intermediates.
- G6P
2. NADPH, ribose-5-phosphate
Which phase of PPP is reversible and which is irreversible?
oxidative phase is irreversible (which produces NADPH and ribose-5-phosphate)
the nonoxidative phase is reversible (which produces the glycolytic intermediates)
Which phase produces NADPH and ribose-5-phosphate? Which phase produces the glycolytic intermediates?
oxidative phase produces NADPH and ribose-5-phosphate
non-oxidative phase produces the glycolytic intermediates
what glycolytic intermediates are produced?
glyceraldehyde-3-phosphate and fructose-6-phosphate
NADPH serves as an important __1___ agent in many anabolic processes, most notably in ___2____ synthesis. It also aids in the neutralization of ____3_____ species
- reducing
- fatty acid
- reactive oxygen
Ribose-5-P is used to synthesize _____
nucleotides
What are done with the glycolytic intermediates at the end of the PPP?
They are shuttled back and reenter the glycolysis pathway
In order for NADPH to be an effective reducing agent, should the ratio of the NADPH to NADP+ in the cell be high or low? Why?
You want a high level of NADPH to NAD+ ratio. This would favor the oxidation of NADPH in order for other molecules to be reduced.
What is the first enzyme in PPP?
glucose-6-phosphate dehydrogenase (G6PDH)
What is the primary point of regulation in PPP?
glucose-6-phosphate dehydrogenase (G6PDH)
What product inhibits G6PDH?
NADPH regulates G6PDH via negative feedback. Increased levels of NADPH inhibit G6PDH.
How many NADPH are created during the oxidative phase of PPP?
2 NADPH molecules
A deficiency of G6PDH enzyme limits the ability of RBCs to eliminate _____ species, which can lead to cell death and potential renal and hepatic complications
reactive oxygen
