Pentose Phosphate Pathway Flashcards
What are the two major productions of the PPP?
NADPH and Ribose 5-phosphate
Where does the PPP happen?
Cytosol
What tissues commonly have PPP active?
Adrenal, Liver, testes, adipose, ovaries, mammary, RBC
What two general functions require NADPH?
Detoxification and reductive synthesis (fatty acids, cholesterol, NT, nts)
T or F: NADPH is used in phagocytosis
T (in the respiratory burst)
How many glucose molecules are needed to go through the PPP?
3
What is the regulated and irreversible step of PPP?
Glucose 6-phosphate to 6-phospho-gluconate. Consumes H20 and generates first NADPH
What are the two irreversible steps of PPP?
Oxidative reactions. Glucose 6-phosphate to 6-phosphogluconate and 6-phosphogluconate to Ribulose 5-phosphate
Which steps of PPP generate NADPH?
Oxidative steps G6P to 6-Phosphogluconate and 6-Phosphogluconate to Ribulose 5-phosphate
Ribulose 5-phosphate is isomerized to?
Ribose 5-phosphate
Ribulose 5-phosphate is epimerized to?
Xylulose 5-phosphate
What happens to Xylulose 5-phosphate?
Tranketolase combines 2 carbons with ribose 5-phosphate to make Sedoheptulose 7-phosphate
What happens to Sedoheptulose 7-phosphate?
Transaldose takes 3 carbons to make Fructose 6-phosphate
What happens to erythrose 4-phosphate?
Transketolase adds 2 carbons from xylulose 5-phosphate to erythrose 4-phosphate to make fructose 6-phosphate
What are the three carbon products that made from PPP?
2 Fructose 6-phosphate and 1 Glyceraldehyde 3-phosphate to be put into glycolytic pathway
