Penicillins

Question 0

Probenecid

Answer 0

Inhibits tubular secretion of drug to prolong half life

Question 1

Mechanism of penicillins

Answer 1

Inhibit cell wall synthesis - Prevents cross linking of peptidoglycan (PBP)

Question 2

Penicillins adverse effects

Answer 2

Hypersensitivity reaction

Diarrhea and super infections (staph, c. dificile)

Question 3

Narrow spectrum penicillins

Answer 3

Penicillin G & V

Question 4

Penicillin G and V uses

Answer 4

Most streptococci and meningococci infections not yet resistant

Question 5

B-lactamase (penicillinase) resistant or antistaphylococcal penicillins

Answer 5

Dicloxacillin
Nafcillin
Oxacillin

Question 6

Uses of dicloxacillin, nafcillin, oxacillin

Answer 6

Resistant staph
MRSA
Acute endocarditis/osteomyelitis, skin/soft tissue infections

Question 7

Extended spectrum of penicillins

Answer 7

Amino penicillins (amoxicillin, ampicillin)
Antipsuedomonal penicillins (piperacillin, ticarcillin)

Question 8

Amoxicillin uses

Answer 8

Otitis media

+ clavulanate for H. Influenzae

Question 9

Ampicillin uses

Answer 9

Meningitis caused by L. monocytogenes

+ sulbactam for bite wounds, diabetic foot ulcers

+ gentamicin for endocarditis

Question 10

Uses of antipseudomonals (piperacillin & ticarcillin)

Answer 10

P. aeruginosa and other gram negative bacteria

+ tazobactam/clavulanate to treat nosocomial pneumonia

Question 11

Penicillins act synergistically with…

Answer 11

Amino glycosides (gentamicin, streptomycin, tobramycin, amikacin)