Cephalosporins

Question 0

First vs subsequent generations

Answer 0

First gen more active against GPC

Subsequent gens more active against GNB and increased B-lactamase resistance

Question 1

Cephalosporin mechanism of action

Answer 1

Cell wall inhibitors

Same mechanism as penicillins, but more B-lactamase resistance

Question 2

First generation activity

Answer 2

PEcK: Proteus mirabilis, E. coli, Klebsiella pneumoniae

Question 3

Cefazolin use

Answer 3

First gen
Surgical prophylaxis
Osteomyelitis

Question 4

Cephalexin

Answer 4

First gen
UTI in pregnant women
Cellulitis/ wound infection

Question 5

Second generation activity against

Answer 5

HENPEcK:

H. influenzae, E. aerogenes, Neisseria species

Question 6

Ceprozil & cefuroxime uses

Answer 6

Second gen
Treat otitis media (due to amoxicillin-resistant H. influenzae)
Community acquired pneumonia

Question 7

Ceftriaxone & cefotaxime uses

Answer 7

Third gen

Drug of choice in meningitis and gonorrhea

Question 8

Ceftazidime use

Answer 8

Third gen

P. aeruginosa