Penicillins

Question 1

Name the Penicillins (6)

Answer 1

Amoxicillin (moderate spectrum)
Ampicillin (moderate spectrum)
Benzyl penicillin (narrow spectrum)
Dicloxacillin (narrow spectrum)
Flucloxacillin (narrow spectrum)
Phenoxymethylpenicillin (narrow spectrum)

Question 2

Penicillins MOA

Answer 2

Interfere with cell wall synthesis by decreasing cross linking of peptidoglycan’s, leading to cell lysis and cell death

Question 3

Name the Pencillins with beta lactamase inhibitors (2)

Answer 3

Amoxicillin with Clavulanic Acid (broad spectrum)
Piperacillin with Tazobactam (broad spectrum)

Question 4

Beta Lactamase Inhibitors MOA

Answer 4

Inhibits beta lactamase (which breaks down normal penicillins), this extends the spectrum of the antibiotic

Question 5

Are Penicillins bactericidal or bacteriostatic?

Answer 5

Bactericidal

Question 6

Common Adverse Effects

Answer 6

Diarrhoea
Nausea
Immunologic reactions (rash)

Question 7

Infrequent Adverse Effects

Answer 7

Vomiting
C.diff

Question 8

Rare Adverse Effects

Answer 8

Electrolyte disturbances
Black tongue
Neurotoxicity