Aminoglycosides

Question 1

Name the Aminoglycoside’s

Answer 1

Amikacin
Gentamycin
Tobramycin
(all IV only)

Question 2

Aminoglycoside’s MOA

Answer 2

Inhibit protein synthesis by irreversibly binding to the 30S ribosomal subunit and causing cell membrane damage

Question 3

Are Aminoglycoside’s bactericidal or bacteriostatic?

Answer 3

Concentration-dependent bactericidal effect

Question 4

Aminoglycoside’s Adverse Effects (common)

Answer 4

Nephrotoxicity
Ototoxicity

Question 5

Aminoglycoside’s Counselling

Answer 5

If given for more than 7 to 10 days the kidneys may work less well, but should improve when stopped (monitor)

Sometimes hearing and balance is effected (ototoxicity)