Penicillins Flashcards
Which classes inhibit cell wall synthesis?
Penicillin Cephalosporins Carbapenems Vancomycin Aztreonam Telavancin
Which classes have Beta-lactam ring?
Penicillin
Cephalosporin
Carbapenems
Monobactams
Bacteria with Beta-lactamase enzyme cannot be killed by?
Antibiotics with beta-lactam ring
MOA: penicillin
- disrupt cell wall synthesis
- Inhibit transpeptidase (essential for building cell wall)
- Activate autolysis
- Bacteria must be GROWING and DIVIDING
How toxic is penicillin?
Low toxicity
Penicillin indications
MANY organisms
-gonorrhea, peritonitis, UTI, PNA, septicemia, Meningitis
What type of bacteria do penicillin’s work on?
Gram (+) mostly
PCN G+V: Indictation
Gram (+) (-) cocci
- anaerobic bacteria
- spirochetes
Natural PCNs
G + V
Least toxic of all PCNs
G + V
G + V can be used with what other antibiotic to get into cell and disrupt protein synthesis
Aminoglycosides
Penicillinase Resistant PCNs
Nafcillin
-Methicillin used to be the choice
Aminopenicillins
Ampicillin Amoxicillin
Which aminocillin is more toxic?
Amoxicillin
PCN used commonly in pediatrics
Amoxicillin
-Ear, nose, throat, GU, skin
Route of Amoxicillin?
PO only
SE: ampicillin
Rash, diarrhea
If oral which aminocillin is a better option?
Amoxicillin
1st broad spectrum PCN
Ampicillin
Wider spectrum than other PCNs
Piperacillin
Ticarcillin + Piperacillin are ALWAYS given with…
Beta-lactamase inhibitor
Piperacillin is used to treat
Pseudomonas
Can affect platelet function and must watch pt’s w/renal dysfunction
Piperacillin
