Penicillins

Question 1

Which classes inhibit cell wall synthesis?

Answer 1

Penicillin
Cephalosporins
Carbapenems
Vancomycin
Aztreonam
Telavancin

Question 2

Which classes have Beta-lactam ring?

Answer 2

Penicillin
Cephalosporin
Carbapenems
Monobactams

Question 3

Bacteria with Beta-lactamase enzyme cannot be killed by?

Answer 3

Antibiotics with beta-lactam ring

Question 4

MOA: penicillin

Answer 4

1. disrupt cell wall synthesis
2. Inhibit transpeptidase (essential for building cell wall)
3. Activate autolysis
4. Bacteria must be GROWING and DIVIDING

Question 5

How toxic is penicillin?

Answer 5

Low toxicity

Question 6

Penicillin indications

Answer 6

MANY organisms

-gonorrhea, peritonitis, UTI, PNA, septicemia, Meningitis

Question 7

What type of bacteria do penicillin’s work on?

Answer 7

Gram (+) mostly

Question 8

PCN G+V: Indictation

Answer 8

Gram (+) (-) cocci

• anaerobic bacteria
• spirochetes

Question 9

Natural PCNs

Answer 9

G + V

Question 10

Least toxic of all PCNs

Answer 10

G + V

Question 11

G + V can be used with what other antibiotic to get into cell and disrupt protein synthesis

Answer 11

Aminoglycosides

Question 12

Penicillinase Resistant PCNs

Answer 12

Nafcillin

-Methicillin used to be the choice

Question 13

Aminopenicillins

Answer 13

Ampicillin Amoxicillin

Question 14

Which aminocillin is more toxic?

Answer 14

Amoxicillin

Question 15

PCN used commonly in pediatrics

Answer 15

Amoxicillin

-Ear, nose, throat, GU, skin

Question 16

Route of Amoxicillin?

Answer 16

PO only

Question 17

SE: ampicillin

Answer 17

Rash, diarrhea

Question 18

If oral which aminocillin is a better option?

Answer 18

Amoxicillin

Question 19

1st broad spectrum PCN

Answer 19

Ampicillin

Question 20

Wider spectrum than other PCNs

Answer 20

Piperacillin

Question 21

Ticarcillin + Piperacillin are ALWAYS given with…

Answer 21

Beta-lactamase inhibitor

Question 22

Piperacillin is used to treat

Answer 22

Pseudomonas

Question 23

Can affect platelet function and must watch pt’s w/renal dysfunction

Answer 23

Piperacillin