HIV drugs Flashcards
1
Q
Nucleotide Reverse Transcriptase Inhibitor (NRTI)
A
Zidovudine
2
Q
Zidovudine
A
When used in combo with other drugs:
- decrease viral load
- delays onset of AIDS
- Reduces symptom severity
SE: severe anemia, neutropenia
-lactic acidosis in female or obese persons
3
Q
Efavirenz
A
NNRTI (reverse transcriptase inhibitor)
USED WITH OTHER DRUGS
SE: Insomnia, Hallucinations, Dizziness
P450 inhibitor and inducer
4
Q
Raltegravir
A
Integrase inhibitor
Metabolized by UGT (caution with inhibitors)
5
Q
Lopiravir/Ritonavir
A
Protease inhibitor
AE:
- hyperglycemia
- lipodystrophy
- hyperlipidemia
- bone loss
CYP450
6
Q
Enfuvirtide
A
Fusion inhibitor
- blocks entry into CD4+ T-cells
- Only use in RESISTANT STRAINS
7
Q
Maraviroc
A
Blocks entry into CD4+ T-cells using CCR5 receptor
-strain must use CCR5 or doesn’t work
LIVER INJURY (Black Box)
