penicillins 1 Flashcards
1
Q
beta lactams lack activity of atypical bacteria such as
A
mycoplasma pneumonia and Chlamydophila pneumonia
2
Q
what parts essential to penicillins?
A
- intact rings
- carboxylic acid
- strained beta lactam ring is a source of instability
3
Q
how does penicillin work
A
- D-ALA D-ALA cleaved and irreversible suicidal inhibition
- block the last step of bacterial cell wall synthesis
4
Q
T or F
- penicillin is bactericidal
A
tTrue
5
Q
resistance mechanisms to penicillins (6 P’s)
A
- penetration
- porins
- pumps
- penicillinase (b-lactamase0
- PBP
- process/pathway
6
Q
gram negative bacteria such as E. Coli, Klesiella, Enterobacter and Proteus are resistant to all anabiotics expect….
A
carbapenems
7
Q
- narrow spectrum (mostly gram positive not producing beta lactamase)
- the most potent penicillin against susceptible gram positive bacteria
- no serious side effects
- acid sensitive so CANNOT be taken orally, only for parenteral use
- sensitive ot beta lactamse
- all pseudomonas and some staph are resistant
- may cause allergy
A
Penicillin G
8
Q
- less active than Pen G
- no serious side effects
- acid stable can be given orally
- sensitive to beta lactamase
- all pseudomonas and some staph are resitant
- more broad spectrum
A
Peniillin V
